Not recommended as a stand-alone test. For initial establishment of diagnosis, refer to Coccidioides Antibodies Reflexive Panel (3001982).
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Serum Separator Tube (SST).
Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens.
Contaminated, hemolyzed, or severely lipemic specimens.
Mark specimens plainly as "acute" or "convalescent."
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
|0.9 IV or less||Negative - No significant level of Coccidioides IgM antibody detected.|
|1.0-1.4 IV||Equivocal - Questionable presence of Coccidioides IgM antibody detected. Repeat testing in 10-14 days may be helpful.|
|1.5 IV or greater||Positive - Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection.|
In most symptomatic patients, IgM antibody usually appears by the second week of infection and disappears by the fourth month. Both tube precipitin (TP) and CF antigens are represented in the ELISA tests.
Negative fungal serology does not rule out the possibility of current infection.
|Component Test Code*||Component Chart Name||LOINC|
|0050178||Coccidioides Antibody, IgM by ELISA||90448-2|
- Cocci IgM
- Coccidioides IgM antibody
- San Joaquin Fever antibodies
- Valley fever antibodies