Ordering Recommendation

Aids in the diagnosis of allergic bronchopulmonary aspergillosis (ABPA) and aspergilloma. For more complete serologic testing, immunodiffusion should be performed in parallel with complement fixation; refer to Aspergillus Antibodies by Complement Fixation and Immunodiffusion (0050101). For diagnosis of invasive aspergillosis, consider ordering Aspergillus Galactomannan Antigen by EIA, Serum (0060068) or Aspergillus Galactomannan Antigen by EIA, Bronchoscopy (2003150).

Mnemonic

ASPER

Methodology

Semi-Quantitative Complement Fixation

Performed

Sun-Sat

Reported

2-5 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.4 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Mark specimens plainly as "acute" or "convalescent."

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Contaminated, hemolyzed, or severely lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

Less than 1:8

Interpretive Data

A titer of 1:8 or greater suggests Aspergillus infection or allergy. Cross-reactions with dimorphic fungi are not unusual within the genus Aspergillus.

Compliance Category

FDA

Note

Hotline History

N/A

CPT Codes

86606

Components

Component Test Code* Component Chart Name LOINC
0050100 Aspergillus Antibodies by CF 5053-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Aspergillosis
Aspergillus Antibodies by Complement Fixation