Ordering Recommendation

Not recommended for the diagnosis of invasive aspergillosis. Consider ordering Aspergillus Galactomannan Antigen by EIA, Serum (0060068) or Aspergillus Galactomannan Antigen by EIA, Bronchoscopy (2003150).

Mnemonic
ASPER
Methodology

Semi-Quantitative Complement Fixation

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.4 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Mark specimens plainly as "acute" or "convalescent."

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Contaminated or severely lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

Less than 1:8

Interpretive Data

Cross-reactions with dimorphic fungi are not unusual with the genus Aspergillus. A negative test does not exclude infection, especially in immunocompromised patients. Best use of the test is with paired sera taken three weeks apart to detect a rise in titer against a single antigen.

Compliance Category

Standard

Note

Negative fungal serology does not rule out the possibility of current infection.

Hotline History
N/A
CPT Codes

86606

Components
Component Test Code* Component Chart Name LOINC
0050100 Aspergillus Antibody by CF 5053-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Aspergillus antibodies CF
Aspergillus Antibody by CF