Aids in the diagnosis of allergic bronchopulmonary aspergillosis (ABPA) and aspergilloma. For more complete serologic testing, immunodiffusion should be performed in parallel with complement fixation; refer to Aspergillus Antibodies by Complement Fixation and Immunodiffusion (0050101). For diagnosis of invasive aspergillosis, consider ordering Aspergillus Galactomannan Antigen by EIA, Serum (0060068) or Aspergillus Galactomannan Antigen by EIA, Bronchoscopy (2003150).
Semi-Quantitative Complement Fixation
New York DOH Approval Status
Serum separator tube.
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.4 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Mark specimens plainly as "acute" or "convalescent."
Contaminated, hemolyzed, or severely lipemic specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Less than 1:8
A titer of 1:8 or greater suggests Aspergillus infection or allergy. Cross-reactions with dimorphic fungi are not unusual within the genus Aspergillus.
|Component Test Code*||Component Chart Name||LOINC|
|0050100||Aspergillus Antibodies by CF||5053-4|