0050047
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Beta-2 Transferrin

B2TRNSF
Example Reports
Abnormal
Normal

Ordering Recommendation

Aids in diagnosis of CSF leak.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Aural or nasal fluid in sterile container (test tube, microtube, syringe).
If submitting syringe, remove needle and cap the end of syringe.

Specimen Preparation

Indicate specimen source.
Submit 2 mL of aural or nasal fluid in sterile container without preservative. (Min: 1 mL of aural or nasal fluid) If direct collection is not feasible, specimen may be collected using a plain cotton swab or gauze and submitted in a sterile container (plain test tube or collection container). Do not add any liquid to the swab or gauze.
Do not collect specimen with a culture swab.

Storage/Transport Temperature

Frozen (preferred) or refrigerated.

Unacceptable Conditions

Specimens grossly contaminated with blood.
Specimens collected with additives (e.g., microbiology media, EDTA, etc.). CSF fluid.

Remarks

Aural or nasal specimens may be contaminated with saliva, which can degrade transferrin protein. These specimens should be frozen immediately after collection and transported in frozen temperature.

Stability

Ambient: 2 weeks; Refrigerated: 2 weeks; Frozen: 2 weeks

Methodology

Qualitative Immunofixation Electrophoresis (IFE)

Performed

Sun-Sat

Reported

1-4 days

Reference Interval

None detected

Interpretive Data

Detection of a beta-2 transferrin band by immunofixation is indicative of the presence of cerebrospinal fluid in the specimen.

Compliance Category

Laboratory Developed Test (LDT)

Note

Beta-2 transferrin is also found in aqueous humor. Rare allelic variants of transferrin may cause false positive results in the detection of CSF leakage. Simultaneous analysis of serum and CSF from the same individual is suggested to rule out these rare false-positive results.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
08/19/2024
X
X
X
N/A

CPT Codes

86335

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Components

Component Test Code* Component Chart Name LOINC
0050047 Beta-2 Transferrin 13876-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Cerebrospinal Fluid Leakage
  • Transferrin, Spinal Fluid
  • B2 Transferrin
  • CSF Leakage Detection
  • CSF Specific Transferrin
  • CSF-Specific Transferrin
  • Desialated Transferrin
  • Tau CSF Protein
  • Transferrin B2
Beta-2 Transferrin