Ordering Recommendation

Use to differentiate LDL particles with respect to size to identify individuals with phenotype A (large LDL particles) or B (small LDL particles); considered as a nontraditional CVD risk marker.

Mnemonic
LDL SUBC
Methodology

Quantitative Electrophoresis

Performed

Thur

Reported

1-8 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Patient should be fasting for 12 hours prior to collection.

Collect

Lavender (EDTA), Pink (K2EDTA), Plain Red, or Serum Separator Tube (SST).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.2 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Heparinized plasma. Specimens from patients receiving heparin. Grossly hemolyzed specimens.

Remarks
Stability

Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: Unacceptable

Reference Interval
Test Number
Components
Reference Interval
  Cholesterol, Total Adults: 199 mg/dL or less
Children: 169 mg/dL or less
  LDL1 (LDL 1 Fraction) 57 mg/dL or less
  LDL2 (LDL 2 Fraction) 30 mg/dL or less
  LDL3 (LDL 3 Fraction) 6 mg/dL or less
  LDL4 (LDL 4 Fraction) None Detected
  LDL5 (LDL 5 Fraction) None Detected
  LDL6 (LDL 6 Fraction) None Detected
  LDL7 (LDL 7 Fraction) None Detected
  Midband A 25 mg/dL or less
  Midband B 15 mg/dL or less
  Midband C 23 mg/dL or less
  VLDL, Cholesterol 22 mg/dL or less
  HDL-Cholesterol 40-59 mg/dL
  Total LDL-Cholesterol 130 mg/dL or less
  LDL Phenotype By report

Interpretive Data

LDL Type A: Indicative of Type A. Type A is characterized by mainly large buoyant LDL.
LDL Not Type A: Not indicative of Type A. Not type A is characterized by mainly small dense LDL. Small dense LDL is associated with an increased risk of coronary artery disease. 

A desirable serum cholesterol concentration in adults is less than 200 mg/dL and less than 170 mg/dL in children. A borderline high serum cholesterol concentration in adults is 200-239 mg/dL and 170-199 mg/dL in children. A high serum cholesterol concentration in adults is greater than 239 mg/dL and greater than 199 mg/dL in children.

Compliance Category

FDA

Note
Hotline History
N/A
CPT Codes

83701; 82465

Components
Component Test Code* Component Chart Name LOINC
0050023 LDL Phenotype 35505-7
0050159 Cholesterol, Total 2093-3
0080531 LDL1 (LDL 1 Fraction) 91105-7
0080532 LDL2 (LDL 2 Fraction) 91106-5
0080533 LDL3 (LDL 3 Fraction) 91107-3
0080534 LDL4 (LDL 4 Fraction) 91108-1
0080535 LDL5 (LDL 5 Fraction) 91109-9
0080536 LDL6 (LDL 6 Fraction) 91110-7
0080537 LDL7 (LDL 7 Fraction) 91111-5
0081007 VLDL, Cholesterol 2091-7
0081008 Midband C 51002-4
0081009 Midband B 51003-2
0081010 Midband A 51004-0
0081011 Total LDL-Cholesterol 2089-1
0081012 HDL-Cholesterol 2085-9
2004029 EER LDL Subclasses 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • LDL fractions
  • LDL phenotype
  • LDL Subfractions
  • LDL Subtype
  • Low Density Lipoprotein Subclass Pattern
LDL Subclasses