May be useful in detecting glomerular basement membrane (GBM) antibodies. Combined use of IFA Glomerular Basement Membrane Antibody, IgG by Multiplex Bead Assay and IFA (2008403) may improve diagnostic sensitivity for disease. If positive, may be useful for monitoring treatment response.
Indirect Fluorescent Antibody
Serum separator tube.
Separate serum from cells ASAP or within 2 hours of collection. Transport 1 mL serum. (Min: 0.5 mL)
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
When present, IgG antibody to glomerular basement membrane (GBM) antigen detected by either indirect fluorescent antibody (IFA) or multiplex bead assay helps support a diagnosis of Goodpasture syndrome. However, the combined result of both assays performed during initial evaluation improves the diagnostic sensitivity for disease. A positive result in one or both assays should be confirmed by renal biopsy.
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
|0049191||GBM Antibody, IgG by IFA||29994-1|
- Anti-GBM Antibody
- Anti-Glomerular Basement Membrane Antibody
- GBM IgG IFA