Ordering Recommendation

Not recommended for detecting protein S deficiency; preferred test is Protein S Free, Antigen (0098894). Use to subtype deficiency in known protein S-deficient individuals in combination with Protein S Free, Antigen (0098894), or Protein S, Functional (0030114). Do not order if individual has been on warfarin therapy in the previous 2-4 weeks.

Mnemonic
PROT S
Methodology

Microlatex Particle-Mediated Immunoassay

Performed

Sun-Sat

Reported

1-2 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.

Specimen Preparation

Transfer 1.5 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Serum. EDTA plasma, clotted or hemolyzed specimens.

Remarks
Stability

Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months, at -70°C: 6 months

Reference Interval
Age Male Female
1-4 days 12-60% 12-60%
5-29 days 22-78% 22-78%
30-89 days 33-93% 33-93%
90-179 days 54-118% 54-118%
180-364 days 55-119% 55-119%
1-5 years 54-118% 54-118%
6-10 years 41-114% 41-114%
11 years and older 84-134% 63-126%

Interpretive Data

Patients on warfarin may have decreased protein S values. Patients should be off warfarin therapy for two weeks for accurate measurement of protein S.

Compliance Category

FDA

Note
Hotline History
N/A
CPT Codes

85305

Components
Component Test Code* Component Chart Name LOINC
0030112 Protein S, Total Antigen 27823-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Free Protein S Antigen
  • Protein S Antigen, S Protein Antigen
  • Total Protein S Antigen
Protein S, Total Antigen