0030114
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Protein S, Functional

PROT S F
Example Reports
Low
Normal

Icon

Specimen Collection and Handling

Ordering Recommendation

Acceptable test for detecting protein S deficiency. Preferred test is Protein S Free, Antigen (0098894). Do not order if the individual has been on warfarin therapy in the previous 2-4 weeks.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.

Specimen Preparation

Transfer 1.5 mL platelet-poor plasma to an ARUP standard transport tube. (Min: 1 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Serum. EDTA plasma, clotted or hemolyzed specimens.

Remarks
Stability

Ambient: 4 hours; Refrigerated: Unacceptable; Frozen: 3 months

Methodology

Electromagnetic Mechanical Clot Detection

Performed

Sun-Sat

Reported

1-2 days

Reference Interval

Test Number
 Components
 Reference Interval
  Protein S Functional
Age Male (%) Female (%)
1-89 days 15-55 15-55
90-179 days 35-92 35-92
180-364 days 45-115 45-115
1-5 years 62-120 62-120
6 years 62-130 62-130
7-9 years 66-140 62-151
10-11 years 65-139 65-142
12-13 years 72-139 70-140
14-15 years 68-145 55-145
16-17 years 77-167 51-147
18 years and older 66-143 57-131

Interpretive Data

Patients on warfarin may have decreased functional protein S values. Patients should be off warfarin therapy for two weeks for accurate measurement of functional protein S. Artificially increased functional protein S values may be due to heparin therapy or the presence of direct thrombin inhibitors or factor Xa inhibitors.

Compliance Category

FDA

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
10/20/2025
X
N/A

CPT Codes

85306

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Components

Component Test Code* Component Chart Name LOINC
0030114 Protein S Functional 27822-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Functional Protein S
  • Protein S Activity, Plasma
Protein S, Functional