Ordering Recommendation

Not recommended except in suspected cases of acquired von Willebrand disease (VWD) or high suspicion of VWD. Preferred initial test is von Willebrand Panel with Reflex to von Willebrand Multimeric Analysis (2003387).




Electrophoresis/Clotting/Microlatex Particle-Mediated Immunoassay/Platelet Agglutination




1-11 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.

Specimen Preparation

Transfer 3 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1.5 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Serum, EDTA plasma, clotted or hemolyzed specimens.


Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months; Frozen at -70°C: 6 months

Reference Interval

Test Number
Reference Interval
  von Willebrand Multimeric Normal
0030095 Factor VIII, Activity
Age Reference Interval
0-6 years 56-191%
7-9 years 76-199%
10-11 years 80-209%
12-13 years 72-198%
14-15 years 69-237%
16-17 years 63-221%
18 years and older 56-191%

0030285 von Willebrand Factor Antigen
Age Reference Interval
0-6 years 52-214%
7-9 years 62-180%
10-11 years 63-189%
12-13 years 60-189%
14-15 years 57-199%
16-17 years 50-205%
18 years and older 52-214%

0030250 von Willebrand Factor Activity (Ristocetin Cofactor)
Age Reference Interval
0-6 years 51-215%
7-9 years 52-176%
10-11 years 60-195%
12-13 years 50-184%
14-15 years 50-203%
16-17 years 49-204%
18 years and older 51-215%

Interpretive Data

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


Hotline History


CPT Codes

85247; 85240; 85246; 85245


Component Test Code* Component Chart Name LOINC
0030003 von Willebrand Multimeric 32217-2
0030095 Factor VIII, Activity 3209-4
0030250 von Willebrand Factor, Activity (RCF) 6014-5
0030285 von Willebrand Factor, Antigen 27816-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Factor VIII
  • Factor VIII, Activity
  • RCF
  • Ristocetin Cofactor
  • von Willebrand Factor, Activity
  • von Willebrand Factor, Antigen
  • von Willebrand Multimeric
  • vW Activity
  • vW multimeric
  • vWAg
  • VWF:A
  • VWF:Rco
von Willebrand Multimeric Panel