Ordering Recommendation

Useful as an indicator of acute toxicity. May be useful as an indicator of deficiency in conjunction with Zinc, Serum or Plasma (0020097).

Mnemonic
ZINC U
Methodology

Quantitative Inductively Coupled Plasma-Mass Spectrometry

Performed

Sun-Sat

Reported

1-5 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician). Collection from patients receiving iodinated or gadolinium-based contrast media must be avoided for a minimum of 72 hours post-exposure. Collection from patients with impaired kidney function should be avoided for a minimum of 14 days post contrast media exposure.

Collect

24 Hour Urine. Refrigerate during collection. Specimen must be collected in a plastic container. Also acceptable: Random Urine.24 Hour Urine. Refrigerate during collection. Specimen must be collected in a plastic container. Also acceptable: Random Urine.

Specimen Preparation

Transfer an 8 mL aliquot from a well-mixed collection to ARUP Trace Element-Free Transport Tubes (ARUP supply #43116) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated. Also acceptable: Room temperature or frozen.

Unacceptable Conditions

Specimens collected within 72 hours after administration of iodinated or gadolinium-based contrast media. Acid preserved urine. Specimens transported in containers other than specified. Specimen contaminated with blood or fecal material.

Remarks

Record total volume and collection time interval on transport tube and on test request form.

Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval

Effective November 13,2017

Test Number
Components
Reference Interval
Zinc, Urine 15.0-120.0 µg/dL
Zinc, Urine-per 24h 150.0-1200.0 µg/d
Zinc, Urine-ratio to CRT 110.0-750.0 µg/gCRT
  Creatinine, Urine - per 24h
Age Male Female
3-8 years 140-700 mg/d 140-700 mg/d
9-12 years 300-1300 mg/d 300-1300 mg/d
13-17 years 500-2300 mg/d 400-1600 mg/d
18-50 years 1000-2500 mg/d 700-1600 mg/d
51-80 years 800-2100 mg/d 500-1400 mg/d
81 years and older 600-2000 mg/d 400-1300 mg/d

Interpretive Data

Zinc is predominantly eliminated in the feces.  Elevated urine zinc may suggest excessive zinc supplementation but should be interpreted with a corresponding serum zinc concentration.

Compliance Category

Laboratory Developed Test (LDT)

Note

High concentrations of iodine or gadolinium may interfere with elemental testing.

Hotline History
N/A
CPT Codes

84630

Components
Component Test Code* Component Chart Name LOINC
0020102 Zinc, Urine - per volume 21610-1
0020103 Zinc, Urine - per 24h 5765-3
0020207 Creatinine, Urine - per volume 2161-8
0020208 Creatinine, Urine - per 24h 2162-6
0025063 Zinc, Urine - ratio to CRT 27201-3
0097110 Total Volume 19153-6
0097111 Hours Collected 30211-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Normalized Urine Zinc
  • urine zinc concentration
  • Zinc/Creatinine Ratio, Random, Urine
  • Zn
  • Zn Urine
  • ZNU
Zinc, Urine