Ordering Recommendation

May be useful as an indicator of acute deficiency. For acute toxicity, Zinc, Urine (0020462) may be a more reliable indicator of exposure.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Diet, medication, and nutritional supplements may introduce interfering substances. Upon the advice of their physician, patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and nonessential over-the-counter medications for one week prior to sample draw.


Royal blue (No Additive), Royal blue (K2EDTA), or Royal blue (NaHep).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection Transfer 2 mL serum or plasma to an ARUP Trace Element-Free Transport Tube (ARUP supply #43116) available online through eSupply using ARUP Connect or contact ARUP Client Services at (800) 522-2787. (Min: 0.5 mL)

Storage/Transport Temperature

Room temperature. Also acceptable: Refrigerated or frozen.

Unacceptable Conditions

Specimens that are not separated from the red cells or clot within 2 hours. Specimens collected in containers other than specified. Specimens transported in containers other than specified. Hemolyzed specimens.


Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Indefinitely


Quantitative Inductively Coupled Plasma-Mass Spectrometry




1-3 days

Reference Interval

60.0-120.0 µg/dL

Interpretive Data

Elevated results may be due to skin or collection-related contamination, including the use of a noncertified metal-free collection/transport tube. If contamination concerns exist due to elevated levels of serum/plasma zinc, confirmation with a second specimen collected in a certified metal-free tube is recommended.

Circulating zinc concentrations are dependent on albumin status and are depressed with malnutrition.  Zinc may also be lowered with infection, inflammation, stress, oral contraceptives, and pregnancy.  Zinc may be elevated with zinc supplementation or fasting.  Elevated zinc concentrations may interfere with copper absorption.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
0020097 Zinc, Serum/Plasma 5763-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • serum zinc level
  • Zn
  • ZNS
Zinc, Serum or Plasma