ADAMTS13 Antibody
Ordering Recommendation

Assist in distinguishing between inherited and acquired forms of thrombotic thrombocytopenic purpura (TTP).  Not recommended as initial test for identification of autoantibodies to ADAMTS13, since the ADAMTS13 antibody test is less specific for acquired TTP than ADAMTS13 Inhibitor (3000228).  Order when acquired TTP is suspected but antibodies are not identified by the ADAMTS13 inhibitor test.  

Quantitative Enzyme-Linked Immunosorbent Assay
1-8 days
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Draw specimen prior to plasma exchange therapy. 
Light Blue (Sodium Citrate). Refer to Specimen Handling at for hemostasis/thrombosis specimen handling guidelines. 
Specimen Preparation
Transfer 1 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL) 
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered. 
Unacceptable Conditions
Serum or EDTA plasma. Clotted or hemolyzed specimens. 
Ambient: 2 hours; Refrigerated: Unacceptable; Frozen: 2 weeks (No freeze/thaw cycles.) 
Reference Interval
Negative: Less than 12 U/mL
Borderline: 12-15 U/mL
Positive: Greater than 15 U/mL
Interpretive Data

Compliance Statement D: For laboratory tests using a manufactured RUO kit. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Hotline History
View Hotline History
Component Test Code*Component Chart NameLOINC
3000192ADAMTS13 Antibody34590-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • VWF Cleaving Protease Antibody