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Coccidioides Antibody by CF, CSF
3000059
Ordering Recommendation

Titers may aid in monitoring coccidioidal meningitis (Valley fever) and treatment response. For initial establishment of diagnosis, refer to Coccidioides Antibodies Panel, CSF by CF, ID, ELISA (3000061) which combines complement fixation, immunodiffusion, and enzyme-linked immunosorbent assays.

Mnemonic
COCCICFCSF
Methodology
Semi-Quantitative Complement Fixation
Performed
Sun-Sat
Reported
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
CSF. 
Specimen Preparation
Transfer 1 mL CSF to an ARUP Standard Transport Tube. (Min 0.6 mL) Parallel testing is preferred and convalescent specimens must be recieved within 30 days from receipt of acute specimens. 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Contaminated, hemolyzed, xanthochromic, or severely lipemic specimens. 
Remarks
Mark specimens plainly as "acute" or "convalescent." 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) 
Reference Interval
Less than 1:2
Interpretive Data
Any titer suggests past or current infection. However, greater than 30 percent of cases with chronic residual pulmonary disease have negative Complement Fixation (CF) tests. Titers of less than 1:32 (even as low as 1:2) may indicate past infection or self-limited disease anticoccidioidal CF antibody titers in excess of 1:16 may indicate disseminated infection. CF serology may be used to follow therapy. Antibody in CSF is considered diagnostic for coccidioidal meningitis, although 10 percent of patients with coccidioidal meningitis will not have antibody in CSF.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
CF measures both IgM and IgG. As single antibody titers are generally not diagnostic, paired specimens are preferred. Acute and convalescent specimens (drawn at least 21 days apart) showing at least a fourfold rise in titer are diagnostic.

Negative fungal serology does not rule out the possibility of current infection.
Hotline History
View Hotline History
Components
Component Test Code*Component Chart NameLOINC
0050711Coccidioides Ab by CF, CSF13917-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Cocci IgG, IgM CF
  • Coccidioidomycosis IgG/IgM
  • San Joaquin Fever Antibody
  • Valley Fever antibodies