Prostate-Specific Kallikrein, 4Kscore
Ordering Recommendation

Test intended for patients 40-80 years of age. Stratifies risk of aggressive prostate cancer in patients with elevated PSA for whom biopsy is being considered. Test should not be ordered if (1) prostate cancer was previously diagnosed; (2) digital rectal exam was performed within the last 4 days; (3) any procedure or therapy was used to treat symptomatic benign prostatic hyperplasia (BPH) within the past 6 months; (4) any invasive, urologic procedure that may be associated with a secondary PSA evaluation was done within the past 6 months; (5) 5-alpha reductase inhibitor (5-ARI) therapy, such as Avodart (dutasteride) or Proscar (finasteride), was administered within the past 6 months.

Electrochemiluminescent Immunoassay
3-6 days
New York DOH Approval Status
This test is New York DOH approved.
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Serum Separator Tube (SST). 
Specimen Preparation
Transfer 4 mL serum to an ARUP Standard Transport Tube. (Min: 3 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Biopsy history must be provided. 
Ambient: Unacceptable; Refrigerated: 72 hours; Frozen: 2 months 
Reference Interval
By report
Interpretive Data

4 Kallikrein Biomarkers: Total PSA, Free PSA, percent free PSA, Intact PSA and hK2. Test should not be ordered if Digital Rectal Exam (DRE) has been performed within the last 4 days or if biopsy history is positive.
Hotline History
View Hotline History
Component Test Code*Component Chart NameLOINC
20140604K - Biopsy History66117-3
20140614K - Digital Rectal Exam (DRE)10205-3
20140634K - Score19146-0
20143094K - PSA, Total
20143104K - PSA, Free83113-1
20143114K - PSA, Percent Free12841-3
30005864K - Order Discussed with Patient59465-5
30005874K - Patient History35090-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • 4K Prostate Screen; Prostate test
  • Kallikrein score

Performed at BioReference Laboratories