Iodine, Serum
Ordering Recommendation

Recommended for determination of iodine excess and monitoring iodine overload in patients administered iodine-containing medications. This test reports total iodine from all iodine-containing species present in the specimen but does not determine the chemical form (species) of the iodine present. For the assessment of nutritional status, Iodine, Urine (2007465) is preferred.

Quantitative Inductively Coupled Plasma-Mass Spectrometry
Tues, Thu, Sat
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, nonessential over-the-counter medications for 48 hours (upon the advice of their physician). In addition, the administration of iodine-based contrast media and drugs containing iodine may yield elevated results. During venipuncture, do not use disinfectants (such as Betadine) that contain iodine. 
Royal blue (no additive). 
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transport 2 mL serum in an ARUP Trace Element-Free Transport Tube (ARUP supply #43116) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 0.5 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Specimens not received in Trace Element Free transport tubes. Separator tubes and specimens that are not separated from the clot within 6 hours. Serum collected within 48 hours after administration of a gadolinium (Gd) or iodine (I) containing contrast media (may occur with MRI studies). Plasma. 
Ambient: 30 days; Refrigerated: 30 days; Frozen: 30 days 
Reference Interval
40-92 µg/L
Interpretive Data
Values greater than 250 µg/L may indicate iodine overload.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Hotline History
Component Test Code*Component Chart NameLOINC
2007464Iodine, Serum2494-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • I serum
  • Iodide
  • serum iodine
  • serum iodine concentration