Aquaporin-4 Receptor Antibody
2003036
Ordering Recommendation
Aids in evaluation of neuromyelitis optica (NMO) and NMO spectrum disorders.
Submit With Order
Mnemonic
AQP4
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Tue
Reported
1-8 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Amniotic fluid, ocular fluid peritoneal fluid, synovial fluid, or plasma. Contaminated, hemolyzed, icteric, or lipemic specimens.  
Remarks
 
Stability
After separation from cells: Ambient: 72 hours; Refrigerated: 2 weeks; Frozen: 1 month (avoid repeated freeze/thaw cycles)  
Reference Interval
Negative: 4 U/mL or less
Indeterminate: 5 U/mL
Positive: 6 U/mL or greater
Interpretive Data
Approximately 75 percent of patients with neuromyelitis optica (NMO) express antibodies to the aquaporin-4 (AQP4) receptor. Diagnosis of NMO requires the presence of longitudinally extensive acute myelitis (lesions extending over 3 or more vertebral segments) and optic neuritis. While absence of antibodies to the AQP4 receptor does not rule out the diagnosis of NMO, presence of this antibody is diagnostic for NMO.

See Compliance Statement D: www.aruplab.com/CS
Note
CPT Code(s)
83516
Components
Component Test Code*Component Chart Name
2003121Aquaporin-4 Receptor Antibody
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Cross References
  • AQP
  • AQP4
  • AQP4 antibody
  • AQP4 ELISA
  • Aquaporin
  • Devic's Ab
  • Devic's Antibody
  • Neuromyelitis Optica (NMO) Antibody
  • Neuromyelitis Optica IgG
  • NMO-IgG
  • Optic Neuritix Ab
  • Optic Neuritix Antibody
  • Optic-Spinal MS Antibody
  • Soft-NMOS
  • Transverse Myelitis Ab
  • Vision Loss Ab