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Aquaporin-4 Receptor Antibody, IgG by IFA with Reflex to Titer, Serum
2013320
Ordering Recommendation

Useful for initial evaluation of NMO spectrum disorders.

Mnemonic
AQP4 SER
Methodology
Semi-Quantitative Indirect Fluorescent Antibody
Performed
Wed
Reported
1-8 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
N/A 
Collect
Serum Separator Tube (SST) or Plain Red. 
Specimen Preparation
Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Contaminated. 
Remarks
N/A 
Stability
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year 
Reference Interval
Less than 1:10
Interpretive Data
Diagnosis of neuromyelitis optica (NMO) requires the presence of longitudinally extensive acute myelitis (lesions extending over 3 or more vertebral segments) and optic neuritis. Approximately 75 percent of patients with NMO express antibodies to the aquaporin-4 (AQP4) receptor. While the absence of AQP4 receptor antibodies does not rule out a diagnosis of NMO, presence of this antibody is diagnostic for NMO.

Compliance Statement D: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
If AQP4 antibody IgG is positive, then an AQP4 antibody IgG titer is reported. Additional charges apply.
CPT Code(s)
86255; if reflexed, add 86256
Components
Component Test Code*Component Chart NameLOINC
2013322Neuromyelitis Optica/AQP4-IgG, Serum44794-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • AQP
  • AQP4
  • AQP4 antibody
  • Aquaporin
  • Devic's Ab
  • Devic's Antibody
  • Neuromyelitis Optica (NMO) Antibody
  • Neuromyelitis Optica IgG
  • NMO-IgG
  • Optic Neuritix Ab
  • Optic Neuritix Antibody
  • Optic-Spinal MS Antibody
  • Soft-NMOS
  • Transverse Myelitis Ab
  • Vision Loss Ab