Cardiolipin Antibodies, IgG and IgM
Ordering Recommendation
Acceptable initial test for strong suspicion of antiphospholipid syndrome (APS). Order with lupus anticoagulant (LA) (0030181) and anti-β2GP1 IgG and IgM assay (0050321).
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Within 24 hours  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)  
Storage/Transport Temperature
Unacceptable Conditions
Plasma or other body fluids. Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.  
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
Test Number Components Reference Interval
0050901Cardiolipin Antibody, IgG 0-​14 GPL: Negative
15-​19 GPL: Indeterminate
20-​80 GPL: Low to Medium positive
81 GPL or above: High positive
0050902Cardiolipin Antibody, IgM 0-​12 MPL: Negative
13-​19 MPL: Indeterminate
20-​80 MPL: Low to Medium Positive
81 MPL or above: High positive
Interpretive Data
Most patients with antiphospholipid antibody syndrome (APS) have medium or high levels of anticardiolipin IgG and/or IgM antibodies. All positive results should be retested on two or more occasions and at least 12 weeks apart to confirm persistence (J Thromb Haemost. 2006;4:295-306).  
GPL = IgG phospholipid units; MPL = IgM phospholipid units
CPT Code(s)
86147 x2
Component Test Code*Component Chart Name
0050901Cardiolipin Antibody IgG
0050902Cardiolipin Antibody IgM
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • ACA
  • aCL
  • aCL Ab
  • aCL antibodies
  • aCL IgG, IgM
  • Anti-Cardiolipin
  • Anti-Phospholipid Antibodies
  • Anticardiolipin
  • Anticardiolipin Antibodies
  • Cardiolip
  • Cardiolipin Antibodies, IgG and IgM, Serum