Serotonin, Serum
0080397
Ordering Recommendation
 
Mnemonic
SEROT-SER
Methodology
Quantitative High Performance Liquid Chromatography
Performed
Sun, Tue-Fri
Reported
1-5 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Abstain from medications for 72 hours prior to collection.  
Collect
Serum separator tube.  
Specimen Preparation
Spin and separate within one hour. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)  
Storage/Transport Temperature
Frozen.  
Unacceptable Conditions
Specimens other than serum. Non-frozen specimens.  
Remarks
  
Stability
After separation from cells: Ambient: Unacceptable; Refrigerated: 24 hours; Frozen: 1 month  
Reference Interval
50-220 ng/mL  
Interpretive Data


See Compliance Statement B: www.aruplab.com/CS
Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
 
Note
Medications that may affect serotonin concentrations include lithium, MAO inhibitors, methyldopa, morphine, and reserpine.  In general, foods that contain serotonin do not interfere significantly.  Slight increases may be seen in acute intestinal obstruction, acute MI, cystic fibrosis, dumping syndromes, and nontropical sprue.  Metastasizing abdominal carcinoid tumors often show serotonin concentrations greater than 400 ng/mL.

In general, EDTA whole blood (as compared to serum) preserved with ascorbic acid will give values most representative of blood concentrations. Most (95 percent) of blood serotonin is found in platelets. Refer to Serotonin, Whole Blood (ARUP test code 0080395).
CPT Code(s)
84260
Components
Component Test Code*Component Chart NameLOINC
0080397Serotonin, Serum27057-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • 5-HT
  • 5-Hydroxy Tryptamine
  • 5-Hydroxytryptamine