Serotonin, Serum
0080397
 
Ordering Recommendation
Mnemonic
SEROT-SER
Methodology
Quantitative High Performance Liquid Chromatography
Performed
Sun, Tue-Fri
Reported
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Abstain from medications for 72 hours prior to collection.  
Collect
Serum separator tube.  
Specimen Preparation
Spin and separate within one hour. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)  
Storage/Transport Temperature
Frozen.  
Unacceptable Conditions
Specimens other than serum. Non-frozen specimens.  
Remarks
 
Stability
After separation from cells: Ambient: Unacceptable; Refrigerated: 24 hours; Frozen: 1 month  
Reference Interval
50-220 ng/mL
Interpretive Data


See Compliance Statement B: www.aruplab.com/CS
Note
Medications that may affect serotonin concentrations include lithium, MAO inhibitors, methyldopa, morphine, and reserpine. In general, foods that contain serotonin do not interfere significantly. Slight increases may be seen in acute intestinal obstruction, acute MI, cystic fibrosis, dumping syndromes, and nontropical sprue. Metastasizing abdominal carcinoid tumors often show serotonin concentrations greater than 400 ng/mL.

In general, EDTA whole blood (as compared to serum) preserved with ascorbic acid will give values most representative of blood concentrations. Most (95 percent) of blood serotonin is found in platelets. Refer to Serotonin, Whole Blood (ARUP test code 0080395).
CPT Code(s)
84260
Components
Component Test Code*Component Chart Name
0080397Serotonin, Serum
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, contact interface support at interface.support@aruplab.com.
Cross References
  • 5-HT
  • 5-Hydroxy Tryptamine
  • 5-Hydroxytryptamine