Use to diagnose and monitor carcinoid tumors. Preferred serotonin test since most of the blood serotonin resides in the platelets.
Quantitative High Performance Liquid Chromatography
Abstain from medications for 72 hours prior to collection.
Lavender (EDTA) or pink (K2EDTA).
Place on ice. Transfer 3 mL whole blood to an ARUP Serotonin Transport Tube containing ascorbic acid (ARUP supply #16568). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 1 mL) Mix well. Specimen must be preserved and frozen within 2 hours of collection.
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Non-frozen specimens. Specimens other than whole blood.
Serotonin, Serum (ARUP test code 0080397) is recommended for patients that are difficult to draw.
After transfer to Serotonin Transport Tube: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 month
Laboratory Developed Test (LDT)
Medications that may affect serotonin concentrations include lithium, MAO inhibitors, methyldopa, morphine, and reserpine. In general, foods that contain serotonin do not interfere significantly. Slight increases may be seen in acute intestinal obstruction, acute MI, cystic fibrosis, dumping syndromes, and nontropical sprue. Metastasizing abdominal carcinoid tumors often show serotonin concentrations greater than 400 ng/mL.
|Component Test Code*||Component Chart Name||LOINC|
|0080395||Serotonin, Whole Blood||2939-7|
- 5-Hydroxy Tryptamine