Ordering Recommendation

Use to diagnose and monitor carcinoid tumors. Preferred serotonin test since most of the blood serotonin resides in the platelets.

Mnemonic
SEROT-WB
Methodology

Quantitative High Performance Liquid Chromatography

Performed

Sun, Tue-Fri

Reported

1-5 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Abstain from medications for 72 hours prior to collection.

Collect

Lavender (EDTA) or pink (K2EDTA).

Specimen Preparation

Place on ice. Transfer 3 mL whole blood to an ARUP Serotonin Transport Tube containing ascorbic acid (ARUP supply #16568). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 1 mL) Mix well. Specimen must be preserved and frozen within 2 hours of collection.

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Non-frozen specimens. Specimens other than whole blood.

Remarks

Serotonin, Serum (ARUP test code 0080397) is recommended for patients that are difficult to draw.

Stability

After transfer to Serotonin Transport Tube: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 month

Reference Interval

50-200 ng/mL

Interpretive Data



Compliance Category

Laboratory Developed Test (LDT)

Note

Medications that may affect serotonin concentrations include lithium, MAO inhibitors, methyldopa, morphine, and reserpine.  In general, foods that contain serotonin do not interfere significantly.  Slight increases may be seen in acute intestinal obstruction, acute MI, cystic fibrosis, dumping syndromes, and nontropical sprue.  Metastasizing abdominal carcinoid tumors often show serotonin concentrations greater than 400 ng/mL.

Hotline History
N/A
CPT Codes

84260

Components
Component Test Code* Component Chart Name LOINC
0080395 Serotonin, Whole Blood 2939-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • 5-HT
  • 5-Hydroxy Tryptamine
  • 5-Hydroxytryptamine
Serotonin, Whole Blood