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Renin Activity
0070105
Ordering Recommendation

The combined aldosterone/renin tests are preferred (refer to Aldosterone/Renin Activity Ratio (0070073) or Aldosterone and Renin, Direct with Ratio (2002582)) when screening for primary hyperaldosteronism.

Mnemonic
RENIN
Methodology
Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun-Sat
Reported
1-2 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Normal sodium diet (100-200 mEq/day) for at least three days. Receiving no medications known to affect renin-aldosterone system.
Supine:
Specimen should be obtained between 8 a.m. and 10 a.m. (after at least two hours in supine position).
OR
Upright:
Specimen should be obtained before noon (after at least two hours in upright position; seated or standing).
Contact Medical Director if more information is needed. 
Collect
From either a supine or upright patient, Lavender (EDTA) or Pink (K2EDTA). Do not collect in refrigerated tubes. 
Specimen Preparation
Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL plasma to an ARUP Standard Transport Tube and freeze immediately. (Min: 1.2 mL) 
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered. 
Unacceptable Conditions
Serum. Specimens collected in citrate, heparin, or oxalate. Hemolyzed specimens. 
Remarks
 
Stability
Ambient: 6 hours; Refrigerated: Unacceptable; Frozen: 1 month 
Reference Interval
Adult, normal sodium diet
Children, normal sodium diet, supine:
Children, normal sodium diet, upright:
Supine: 0.2-1.6 ng/mL/hrNewborn (1-7 days): 2.0-35.0 ng/mL/hr0-3 years: Not Available
Upright: 0.5-4.0 ng/mL/hrCord blood: 4.0-32.0 ng/mL/hr4-5 years: Less than or equal to 15 ng/mL/hr
1-12 months: 2.4-37.0 ng/mL/hr6-10 years: Less than or equal to 17 ng/mL/hr
13 months-3 years:1.7-11.2 ng/mL/hr11-15 years: Less than or equal to 16 ng/mL/hr
4-5 years:1.0-6.5 ng/mL/hr
6-10 years: 0.5-5.9 ng/mL/hr
11-15 years: 0.5-3.3 ng/mL/hr

Interpretive Data
Plasma renin activity measures enzyme ability to convert angiotensinogen to angiotensin I and is limited by the availability of angiotensinogen. Plasma renin activity is not an accurate indicator of enzyme activity when angiotensinogen is decreased.

Compliance Statement D: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
CPT Code(s)
84244
Components
Component Test Code*Component Chart NameLOINC
0070105Renin Activity2915-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Plasma Renin Activity
  • PRA
  • Renin Activity, Plasma