Renin Activity
0070105
Ordering Recommendation
 
Mnemonic
RENIN
Methodology
Quantitative Radioimmunoassay
Performed
Sun-Sat
Reported
1-2 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Supine: 1. Specimen should be obtained between 8 a.m. and 10 a.m. (after at least two hours in supine position); 2. Normal sodium diet (100-200 mEq/day) for at least three days; 3. Take no medications known to affect renin-aldosterone system.  
Upright:
1. Specimen should be obtained before noon (after at least two hours in upright position; seated or standing); 2. Normal sodium diet (100-200 mEq/day) for at least three days; 3. Take no medications known to affect renin-aldosterone system.
Contact Medical Director if more information is needed.  
Collect
Lavender (EDTA) or pink (K2EDTA). Do not collect in refrigerated tubes.  
Specimen Preparation
Separate plasma from cells. Transfer 2 mL plasma to an ARUP Standard Transport Tube and freeze immediately. (Min: 1.2 mL)  
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.  
Unacceptable Conditions
Serum. Specimens collected in citrate, heparin, or oxalate. Hemolyzed or refrigerated specimens.  
Remarks
  
Stability
After separation from cells: Ambient: 6 hours; Refrigerated: Unacceptable; Frozen: 1 month  
Reference Interval
 
 
Adult, normal sodium diet Children, normal sodium diet, supine:  Children, normal sodium diet, upright: 
Supine: 0.2-​1.6 ng/mL/hr Newborn (1-​7 days): 2.0-​35.0 ng/mL/hr 0-​3 years: Not Available
Upright: 0.5-​4.0 ng/mL/hr Cord blood: 4.0-​32.0 ng/mL/hr 4-​5 years: Less than or equal to 15 ng/mL/hr
 1-​12 months: 2.4-​37.0 ng/mL/hr 6-​10 years: Less than or equal to 17 ng/mL/hr
 13 months-​3 years:1.7-​11.2 ng/mL/hr 11-​15 years: Less than or equal to 16 ng/mL/hr
 4-​5 years:1.0-​6.5 ng/mL/hr  
 6-​10 years: 0.5-​5.9 ng/mL/hr  
 11-​15 years: 0.5-​3.3 ng/mL/hr  
Interpretive Data
Plasma renin activity measures enzyme ability to convert angiotensinogen to angiotensin I and is limited by the availability of angiotensinogen. Plasma renin activity is not an accurate indicator of enzyme activity when angiotensinogen is decreased.  
Note
 
CPT Code(s)
84244
Components
Component Test Code*Component Chart NameLOINC
0070105Renin Activity2915-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Plasma Renin Activity
  • PRA
  • Renin Activity, Plasma