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Tissue Transglutaminase Antibody, IgG
0056009
Ordering Recommendation

Recommended single screening test for celiac disease. IgA testing recommended to identify IgA deficiency. Use IgG test in individuals who are IgA deficient. May aid in monitoring adherence to gluten-free diet.

Mnemonic
TTG G
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun-Sat
Reported
1-2 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube.  
Specimen Preparation
Remove serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Plasma. Hemolyzed or severely lipemic specimens.  
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year  
Reference Interval
5 U/mL or less: Negative
6-9 U/mL: Weak Positive
10 U/mL or greater: Positive
Interpretive Data
The tTG IgG assay may aid in the diagnosis of gluten-sensitivity enteropathy (i.e., celiac disease, dermatitis herpetiformis) in tTG IgA negative patients with confirmed IgA deficiency. A negative tTG IgG test alone does not rule out gluten-sensitive enteropathy.


Note
Human recombinant tTG antigen is utilized in this assay
CPT Code(s)
83516
Components
Component Test Code*Component Chart NameLOINC
0056009Tissue Transglutaminase Antibody,IgG56537-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Tissue Transglutaminase
  • Transglutaminase
  • tTG
  • tTG IgG