Tissue Transglutaminase Antibody, IgG
0056009
Ordering Recommendation
Use in IgA-deficient individuals; recommended single screening test for celiac disease. In confirmed disease, this test may be used for monitoring.
Mnemonic
TTG G
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun-Sat
Reported
1-2 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Serum separator tube.  
Specimen Preparation
Remove serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Plasma. Hemolyzed or severely lipemic specimens.  
Remarks
  
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year  
Reference Interval
< 20 EU: None Detected
20-30 EU: Weakly Positive
> 30 EU: Positive  
Interpretive Data
The tTG IgG assay may aid in the diagnosis of gluten-sensitivity enteropathy (i.e., celiac disease, dermatitis herpetiformis) in tTG IgA negative patients with confirmed IgA deficiency. A negative tTG IgG test alone does not rule out gluten-sensitive enteropathy.  
Note
Native human tTG antigen is utilized in this assay
CPT Code(s)
83516
Components
Component Test Code*Component Chart Name
0056009Tissue Transglutaminase Antibody,IgG
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Aliases
  • Tissue Transglutaminase
  • Transglutaminase
  • tTG
  • tTG IgG