Feedback
Tissue Transglutaminase Antibody, IgG
0056009
Ordering Recommendation

• Recommended single screening test for IgA-deficient individuals with suspected celiac disease. (IgA testing recommended to identify IgA deficiency.)
• May aid in monitoring adherence to gluten-free diet in celiac disease confirmed patients.

Mnemonic
TTG G
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun-Sat
Reported
1-2 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube. 
Specimen Preparation
Remove serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Plasma. Hemolyzed or severely lipemic specimens. 
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year 
Reference Interval
5 U/mL or less: Negative
6-9 U/mL: Weak Positive
10 U/mL or greater: Positive
Interpretive Data
The tTG IgG assay may aid in the diagnosis of gluten-sensitivity enteropathy (i.e., celiac disease, dermatitis herpetiformis) in tTG IgA negative patients with confirmed IgA deficiency. A negative tTG IgG test alone does not rule out gluten-sensitive enteropathy.

Note
Human recombinant tTG antigen is utilized in this assay
CPT Code(s)
83516
Components
Component Test Code*Component Chart NameLOINC
0056009Tissue Transglutaminase Antibody,IgG56537-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Tissue Transglutaminase
  • Transglutaminase
  • tTG
  • tTG IgG