Tissue Transglutaminase Antibody, IgG
0056009
 
Ordering Recommendation
Use in IgA-deficient individuals; recommended single screening test for celiac disease. In confirmed disease, this test may be used for monitoring.
Mnemonic
TTG G
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun-Sat
Reported
1-2 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Serum separator tube.  
Specimen Preparation
Remove serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Plasma. Hemolyzed or severely lipemic specimens.  
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year  
Reference Interval
< 20 EU: None Detected
20-30 EU: Weakly Positive
> 30 EU: Positive
Interpretive Data
The tTG IgG assay may aid in the diagnosis of gluten-sensitivity enteropathy (i.e., celiac disease, dermatitis herpetiformis) in tTG IgA negative patients with confirmed IgA deficiency. A negative tTG IgG test alone does not rule out gluten-sensitive enteropathy.
Note
Native human tTG antigen is utilized in this assay
CPT Code(s)
83516
Components
Component Test Code*Component Chart Name
0056009Tissue Transglutaminase Antibody,IgG
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, contact interface support at interface.support@aruplab.com.
Cross References
  • Tissue Transglutaminase
  • Transglutaminase
  • tTG
  • tTG IgG