Toll-like receptors (TLR), PAM3CSK4, synthetic bacterial lipoprotein (TLR2-TLR1 ligand); zymosan cell wall particles from Saccharomyces cerevisiae
(TLR6-TLR2 ligand); poly(I:C), synthetic analog of dsRNA (TLR3 ligand); lipopolysaccharide ultra pure S. minnesota
LPS (TLR4 ligand); flagellin purified from S. typhimurium
(TLR5 ligand); and CL097 imidazoquinoline compound (TLR7-TLR8 ligand),
are tested independently in peripheral blood mononuclear cell (PBMC) culture. PBMC cytokine production responses to these mitogens are determined by multi-analyte fluorescence detection.
Compliance Statement B
: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.