F-Actin (Smooth Muscle) Antibody, IgG by ELISA with Reflex to Smooth Muscle Antibody, IgG Titer
0051174
Ordering Recommendation
 
Mnemonic
SMA R
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody
Performed
Sun-Sat
Reported
1-5 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube.(Min: 0.25 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Plasma. Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.  
Remarks
  
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year  
Reference Interval
 
 
Test Number Components Reference Interval
0055248F-​Actin (Smooth Muscle) Antibody, IgG Effective May 16, 2011
 
19 Units or less Negative
20-​30 Units Weak Positive -​ Suggest repeat testing in two to three weeks with fresh specimen.
31 Units or greater Positive -​ Suggestive of autoimmune hepatitis type 1 or chronic active hepatitis.
0051244Smooth Muscle Antibody, IgG Titer <1:20 = Normal -​ No antibody detected.
1:20-​1:80 = Weak Positive -​ Suggest repeat testing in two to three weeks with fresh specimen.
1:160 or greater = Positive -​ Suggestive of autoimmune hepatitis or chronic active hepatitis.
Interpretive Data
Refer to report.  
Note
In viral hepatitis the titers are generally less than 1:80 and are transient. The titers in primary biliary cirrhosis are also low, ranging from 1:20 to 1:40.

If F-Actin is 20 Units or greater, then Smooth Muscle Ab, IgG IFA titer will be added. Additional charges apply
CPT Code(s)
83516; if reflexed, add 86256
Components
Component Test Code*Component Chart NameLOINC
0055248F-Actin (Smooth Muscle) Ab, IgG by ELISA44706-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Actin Antibody
  • Actin Antibody Reflexive Panel
  • Anti-Smooth Muscle Antibody
  • ASMA
  • ASMA Reflexive Panel
  • F-Actin Antibody
  • F-Actin Antibody Panel
  • SMA
  • SMA IgG
  • SMA IgG Ab
  • SMA Reflexive Panel
  • Smooth Muscle Antibodies
  • Soft-SMA