F-Actin (Smooth Muscle) Antibody, IgG by ELISA with Reflex to Smooth Muscle Antibody, IgG Titer
Ordering Recommendation

May be helpful in evaluating for autoimmune liver disease. For a more comprehensive reflex panel, refer to Autoimmune Liver Disease Evaluation with Reflex to Smooth Muscle Antibody (SMA), IgG by IFA (2007210).

Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Serum separator tube. 
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube.(Min: 0.25 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Plasma. Contaminated, heat-inactivated, hemolyzed, or lipemic specimens. 
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year 
Reference Interval
Test Number
Reference Interval
0055248F-Actin (Smooth Muscle) Antibody, IgG (INACTIVE as of 05/15/17: Refer to 2007210, 0051174, 2007209)Effective May 16, 2011
19 Units or lessNegative
20-30 UnitsWeak Positive - Suggest repeat testing in two to three weeks with fresh specimen.
31 Units or greaterPositive - Suggestive of autoimmune hepatitis type 1 or chronic active hepatitis.

0051244Smooth Muscle Antibody, IgG Titer
Less than 1:20Negative - No Antibody detected.
1:20-1:80Weak Positive - Suggest repeat testing in two to three weeks with fresh specimen.
1:160 or greaterPositive - Suggestive of autoimmune hepatitis or chronic active hepatitis.

Interpretive Data
Refer to report.

In viral hepatitis the titers are generally less than 1:80 and are transient. The titers in primary biliary cirrhosis are also low, ranging from 1:20 to 1:40.

If F-Actin is 20 Units or greater, then Smooth Muscle Ab, IgG IFA titer will be added. Additional charges apply
CPT Code(s)
Component Test Code*Component Chart NameLOINC
0055248F-Actin (Smooth Muscle) Ab, IgG by ELISA44706-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Actin Antibody
  • Actin Antibody Reflexive Panel
  • Anti-Smooth Muscle Antibody
  • ASMA
  • ASMA Reflexive Panel
  • F-Actin Antibody
  • F-Actin Antibody Panel
  • SMA
  • SMA IgG
  • SMA IgG Ab
  • SMA Reflexive Panel
  • Smooth Muscle Antibodies
  • Soft-SMA