Not recommended as a stand-alone test. Refer to the combined complement fixation and immunodiffusion test (0050627).
- Patient Preparation
- Serum separator tube.
- Specimen Preparation
- Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.25 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of acute specimens. Mark specimens plainly as acute or convalescent.
- Storage/Transport Temperature
- Unacceptable Conditions
- Contaminated or severely lipemic specimens.
- After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
|Test Number||Components||Reference Interval|
| ||Histoplasma Mycelia, CF||Less than 1:8|
| ||Histoplasma Yeast, CF||Less than 1:8|
Yeast phase is regarded as more sensitive. Approximately 90-95 percent of cases have positive titers to one or both antigens. Titers to mycelial antigen are higher in chronic infection. Cross-reactions, usually at lower titers, may occur with other fungal disease. Rising titers suggest progression of infection. Skin tests in individuals previously exposed may cause titer elevation in 17-20 percent of cases.
|Component Test Code*||Component Chart Name||LOINC|
|0050330||Histoplasma Mycelia, CF||20573-2|
|0050335||Histoplasma Yeast, CF||20574-0|
- H. Mycelia Ab
- Histoplasma Yeast Ab
- Histoplasmosis Antibody