Coccidioides Antibodies Panel, Serum by CF, ID, ELISA
0050588
Ordering Recommendation
 
Mnemonic
COCCI PAN
Methodology
Semi-Quantitative Complement Fixation/Qualitative Immunodiffusion/Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Refer to individual components
Reported
2-5 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer two 1 mL aliquots of serum to individual ARUP Standard Transport Tube. (Min: 0.3 mL per aliquot) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Mark specimens plainly as "acute" or "convalescent."  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.  
Remarks
  
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
Effective November 18, 2013
 
Test Number Components Reference Interval
0050170Coccidioides Antibody by CF Less than 1:2
0050183Coccidioides immitis Antibodies by Immunodiffusion None detected.
0050179Coccidioides Antibody, IgG by ELISA 0.9 IV or less: Negative-​ No significant level of Coccidioides IgG antibody detected.
1.0-​1.4 IV: Equivocal -​ Questionable presence of Coccidioides IgG antibody detected.  Repeat testing in 10-​14 days may be helpful.
1.5 IV or greater: Positive -​ Presence of IgG antibody to Coccidioides detected, suggestive of current or past infection.
0050178Coccidioides Antibody, IgM by ELISA 0.9 IV or less: Negative -​ No significant level of Coccidioides IgM antibody detected.
1.0-​1.4 IV: Equivocal -​ Questionable presence of Coccidioides IgM antibody detected.  Repeat testing in 10-​14 days may be helpful.
1.5 IV or greater: Positive -​ Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection.
Interpretive Data
Refer to individual components.  
Note
For Coccidioides, immunodiffusion (ID) measures IgM antibodies, while complement fixation (CF) measures both IgG and IgM. ELISA tests can be used to detect both coccidioidal IgG and IgM antibodies. While elevated single antibody titers may be diagnostic, paired specimens are preferred.  Acute and convalescent specimens (drawn at least 21 days apart), showing a fourfold or greater rise in titer, are diagnostic.

Negative fungal serology does not rule out the possibility of current infection.
CPT Code(s)
86635 x4
Components
Component Test Code*Component Chart NameLOINC
0050170Coccidioides Antibody by CF33380-7
0050178Coccidioides Antibody, IgM by ELISA33510-9
0050179Coccidioides Antibody, IgG by ELISA31154-8
0050183Coccidioides immitis Abs, Precipitin31153-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Cocci Antibodies Panel
  • COCCI CF,ID,ELISA
  • Coccidioides Antibodies Serum panel
  • San Joaquin Fever Antibodies
  • Valley Fever Antibodies