Saccharomyces cerevisiae Antibodies, IgG & IgA
0050564
 
Ordering Recommendation
Aids in differentiating Crohn disease from ulcerative colitis in individuals with inflammatory bowel disease. Inflammatory Bowel Disease Differentiation Profile (0050567) is the preferred test.
Mnemonic
SC PAN
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun-Sat
Reported
1-2 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Contaminated, heat-inactivated, hemolyzed, or severely lipemic specimens.  
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
Test Number Components Reference Interval
Saccharomyces cerevisiae Antibody, IgG 20.0 Units or less: Negative
20.1-​24.9 Units: Equivocal
25.0 Units or greater: Positive
Saccharomyces cerevisiae Antibody, IgA 20.0 Units or less: Negative
20.1-​24.9 Units: Equivocal
25.0 Units or greater: Positive
Interpretive Data
Saccharomyces cerevisiae IgG antibodies are found in 60-70% of Crohn disease (CD) patients and 10-15% of ulcerative colitis (UC) patients. Saccharomyces cerevisiae IgA antibodies are found in about 35% of CD patients but less than 1% in UC patients. Detection of both Saccharomyces IgG and IgA antibodies in the same serum specimen is highly specific for CD.
Note
This test may be a useful tool for distinguishing ulcerative colitis (UC) from Crohn disease (CD) in patients with suspected inflammatory bowel disease.
CPT Code(s)
86671 x2
Components
Component Test Code*Component Chart Name
0050562S. cerevisiae Antibody, IgG
0050563S. cerevisiae Antibody, IgA
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, contact interface support at interface.support@aruplab.com.
Cross References
  • ASCA
  • ASCA Abs
  • ASCA IgA
  • ASCA IgG
  • S. cerevisiae