Saccharomyces cerevisiae Antibodies, IgG & IgA
Ordering Recommendation
Aids in differentiating Crohn disease from ulcerative colitis in individuals with inflammatory bowel disease. Inflammatory Bowel Disease Differentiation Profile (0050567) is the preferred test.
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
1-2 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)  
Storage/Transport Temperature
Unacceptable Conditions
Contaminated, heat-inactivated, hemolyzed, or severely lipemic specimens.  
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
Test Number Components Reference Interval
 Saccharomyces cerevisiae Antibody, IgG  20.0 Units or less: Negative
20.1-​24.9 Units: Equivocal
25.0 Units or greater: Positive
 Saccharomyces cerevisiae Antibody, IgA 20.0 Units or less: Negative
20.1-​24.9 Units: Equivocal
25.0 Units or greater: Positive
Interpretive Data
Saccharomycescerevisiae IgG antibodies are found in 60-70% of Crohn disease (CD) patients and 10-15% of ulcerative colitis (UC) patients. Saccharomyces cerevisiae IgA antibodies are found in about 35% of CD patients but less than 1% in UC patients. Detection of both Saccharomyces IgG and IgA antibodies in the same serum specimen is highly specific for CD.  
This test may be a useful tool for distinguishing ulcerative colitis (UC) from Crohn disease (CD) in patients with suspected inflammatory bowel disease.
CPT Code(s)
86671 x2
Component Test Code*Component Chart NameLOINC
0050562S. cerevisiae Antibody, IgG47321-5
0050563S. cerevisiae Antibody, IgA47320-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • ASCA
  • ASCA Abs
  • ASCA IgA
  • ASCA IgG
  • S. cerevisiae