Saccharomyces cerevisiae Antibodies, IgG & IgA
Ordering Recommendation
Aids in differentiating Crohn disease from ulcerative colitis in individuals with inflammatory bowel disease. Inflammatory Bowel Disease Differentiation Profile (0050567) is the preferred test.
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
1-2 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)  
Storage/Transport Temperature
Unacceptable Conditions
Contaminated, heat-inactivated, hemolyzed, or severely lipemic specimens.  
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
Test Number Components Reference Interval
Saccharomyces cerevisiae Antibody, IgG 20.0 Units or less: Negative
20.1-​24.9 Units: Equivocal
25.0 Units or greater: Positive
Saccharomyces cerevisiae Antibody, IgA 20.0 Units or less: Negative
20.1-​24.9 Units: Equivocal
25.0 Units or greater: Positive
Interpretive Data
Saccharomyces cerevisiae IgG antibodies are found in 60-70% of Crohn disease (CD) patients and 10-15% of ulcerative colitis (UC) patients. Saccharomyces cerevisiae IgA antibodies are found in about 35% of CD patients but less than 1% in UC patients. Detection of both Saccharomyces IgG and IgA antibodies in the same serum specimen is highly specific for CD.
This test may be a useful tool for distinguishing ulcerative colitis (UC) from Crohn disease (CD) in patients with suspected inflammatory bowel disease.
CPT Code(s)
86671 x2
Component Test Code*Component Chart Name
0050562S. cerevisiae Antibody, IgG
0050563S. cerevisiae Antibody, IgA
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, contact interface support at
Cross References
  • ASCA
  • ASCA Abs
  • ASCA IgA
  • ASCA IgG
  • S. cerevisiae