Beta-2 Glycoprotein 1 Antibodies, IgG and IgM
0050321
Ordering Recommendation
Acceptable initial test when antiphospholipid syndrome (APS) is strongly suspected. Order with lupus anticoagulant (LA) (0030181) and anticardiolipin (aCL) IgG and IgM (0099344) assays.
Mnemonic
B2GPI PAN
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun-Sat
Reported
1-2 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Plasma or other body fluids. Contaminated, hemolyzed, grossly icteric, or severely lipemic specimens.  
Remarks
  
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
 
 
Test Number Components Reference Interval
 Beta-​2 Glycoprotein 1 Antibody, IgG Effective August 18, 2014
0-​20 SGU
 Beta-​2 Glycoprotein 1 Antibody, IgM Effective August 18, 2014
0-​20 SMU
Interpretive Data
The persistent presence of IgG and/or IgM beta 2 glycoprotein I (B2GPI) antibodies (greater than 99th percentile) is a laboratory criterion for the diagnosis of antiphospholipid syndrome (APS). Persistence is defined as moderate or high levels of IgG and/or IgM B2GPI antibodies detected in two or more specimens drawn at least 12 weeks apart (J Throm Haemost. 2006;4:295-306). B2GPI results greater than 20 SGU (IgG) and/or SMU (IgM) are considered positive based on the cutoff values established for this test. International reference materials and consensus units for anti-B2GPI antibodies have not been established (Clin Chim Acta. 2012;413(1-2):358-60; Arthritis Rheum. 2012;64(1):1-10.). Strong clinical correlation is recommended for a diagnosis of APS. Low positive IgG and IgM B2GPI antibody levels should be interpreted in light of APS-specific clinical manifestations and/or other criteria phospholipid antibody tests.  
Note
 
CPT Code(s)
86146 x2
Components
Component Test Code*Component Chart NameLOINC
0050322B2Glycoprotein 1, IgG Antibody44448-9
0050323B2Glycoprotein 1, IgM Antibody44449-7
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Aliases
  • ?2-glycoprotein 1 antibodies
  • Anti-B2-Glycoprotein 1
  • Anti-B2-Glycoprotein I (Beta-2 Glycoprotein 1 Antibodies, IgG & IgM)
  • Anti-B2-GP 1
  • Anti-B2-GP1
  • Anti-B2-GPI
  • Anti-beta-2 glycoprotein 1
  • Anti-Beta-2-Glycoprotein I
  • Apolipoprotein H
  • Apolipoprotein H, APOH
  • B2GP Antibodies
  • B2GP1
  • B2GPI IgG, IgM, IgA
  • BECKY
  • Beta 2 GP1 Ab IgA
  • Beta 2 GP1 Ab IgG
  • Beta 2 GP1 Ab IgM
  • Beta 2GP1 Ab
  • Beta-2 Glycoprotein 1