Coccidioides Antibody by CF
0050170
Ordering Recommendation
 
Mnemonic
COCCI
Methodology
Semi-Quantitative Complement Fixation
Performed
Sun-Sat
Reported
1-3 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Serum separator tube OR CSF.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum OR CSF to an ARUP Standard Transport Tube. (Min: 0.15 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of acute specimens. Mark specimens plainly as acute or convalescent.  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Contaminated or severely lipemic specimens.  
Remarks
  
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
Less than 1:2  
Interpretive Data
Any titer suggests past or current infection. However, greater than 30 percent of cases with chronic residual pulmonary disease have negative Complement Fixation (CF) tests. Titers of less than 1:32 (even as low as 1:2) may indicate past infection or self-limited disease; titers greater than or equal to 1:32 may indicate disseminated infection. CF serology may be used to follow therapy. Antibody in CSF is considered diagnostic for coccidioidal meningitis, although 10 percent of patients with coccidioidal meningitis will not have antibody in CSF.  
Note
CF measures both IgM and IgG. As single antibody titers are generally not diagnostic, paired specimens are preferred. Acute and convalescent specimens (drawn at least 21 days apart), showing at least a fourfold rise in titer, are diagnostic.

Negative fungal serology does not rule out the possibility of current infection.
CPT Code(s)
86635
Components
Component Test Code*Component Chart Name
0050170Coccidioides Antibody by CF
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Aliases
  • Cocci IgG, IgM CF
  • Coccidioidomycosis IgG/IgM
  • San Joaquin Fever Antibody
  • Valley Fever antibodies