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Coccidioides Antibodies by Complement Fixation
Ordering Recommendation
Use to monitor coccidioidal antibody titer in serum in response to treatment. For initial diagnosis of coccidioidomycosis, refer to Coccidioides Antibodies Reflexive Panel, Serum (3001982).
New York DOH Approval Status
Specimen Required
Serum separator tube (SST).
Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP standard transport tube. (Min: 0.6 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of acute specimens..
Refrigerated.
Other body fluids. Contaminated, hemolyzed, icteric, or lipemic specimens.
Mark specimens plainly as "acute" or "convalescent."
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Methodology
Semi-Quantitative Complement Fixation
Performed
Sun-Sat
Reported
2-5 days
Reference Interval
Less than 1:2
Interpretive Data
A titer of 1:2 or greater suggests past or current infection. However, greater than 30 percent of cases with chronic residual pulmonary disease have negative complement fixation (CF) tests. Titers of less than 1:32 (even as low as 1:2) may indicate past infection or self-limited disease; anticoccidioidal CF antibody titers in excess of 1:16 may indicate disseminated infection. CF serology may be used to follow therapy. Antibody in CSF is considered diagnostic for coccidioidal meningitis, although 10 percent of patients with coccidioidal meningitis will not have antibody in CSF.
FDA
Note
Hotline History
CPT Codes
86635
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0050170 | Coccidioides Antibody by CF | 33380-7 |
Aliases
- Coccidioidomycosis
- Valley Fever
- Coccidioides immitis
