APC Resistance Profile
0030127
Ordering Recommendation
Acceptable initial test to detect activated protein C resistance due to a factor V Leiden mutation. Preferred test is APC Resistance Profile with Reflex to Factor V Leiden (0030192).  However, Factor V Leiden (F5) R506Q Mutation (0097720) is the preferred initial test for individuals with supratherapeutic concentrations of heparin, direct thrombin inhibitors, extreme factor V deficiency, or lupus anticoagulants with markedly prolonged baseline clotting times.
Mnemonic
APC RST
Methodology
Electromagnetic Mechanical Clot Detection
Performed
Mon-Sat
Reported
1-4 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.  
Specimen Preparation
Transfer 1.5 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1 mL)  
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.  
Unacceptable Conditions
Serum. EDTA plasma or hemolyzed specimens.  
Remarks
  
Stability
Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months; Frozen at -70°C: 6 months
   
Reference Interval
2.0 or greater  
Interpretive Data
Ratios less than 2.00 suggest APC resistance. This method uses factor V deficient plasma; therefore, APC resistance due to a nonfactor V mutation will not be detected. Extreme factor V deficiency may cause abnormal ratio.  
Note
 
CPT Code(s)
85307
Components
Component Test Code*Component Chart NameLOINC
0030127APC Resistance Panel13590-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Activated Protein C Resistance
  • APCR
  • Factor V Leiden Functional Assay
  • Protein C Resistance