APC Resistance Profile
Acceptable initial test to detect activated protein C resistance due to a factor V Leiden mutation. Preferred test is APC Resistance Profile with Reflex to Factor V Leiden (0030192). However, Factor V Leiden (F5) R506Q Mutation (0097720) is the preferred initial test for individuals with supratherapeutic concentrations of heparin, direct thrombin inhibitors, extreme factor V deficiency, or lupus anticoagulants with markedly prolonged baseline clotting times.
New York DOH Approval Status
This test is New York DOH approved.
- Patient Preparation
- Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.
- Specimen Preparation
- Transfer 1.5 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1 mL)
- Storage/Transport Temperature
- Unacceptable Conditions
- Serum. Non-frozen or hemolyzed specimens.
- Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months; Frozen at -70°C: 6 months
2.0 or greater
Ratios less than 2.00 suggest APC resistance. This method uses factor V deficient plasma; therefore, APC resistance due to a nonfactor V mutation will not be detected. Extreme factor V deficiency may cause abnormal ratio.
|Component Test Code*||Component Chart Name|
|0030127||APC Resistance Panel|
- Activated Protein C Resistance (APCR)
- Factor V Leiden Functional Assay
- Protein C Resistance