von Willebrand Multimeric Panel
Ordering Recommendation

Not recommended except in suspected cases of acquired von Willebrand disease (VWD) or high suspicion of VWD. Preferred initial test is von Willebrand Panel with Reflex to von Willebrand Multimeric Analysis (2003387).

Electrophoresis/Clotting/Microlatex Particle-Mediated Immunoassay/Platelet Agglutination
1-11 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Lt. blue (sodium citrate). Refer to Specimen Handling at for hemostasis/thrombosis specimen handling guidelines. 
Specimen Preparation
Transfer 3 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1.5 mL) 
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered. 
Unacceptable Conditions
Serum, EDTA plasma, clotted or hemolyzed specimens. 
Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months; Frozen at -70°C: 6 months 
Reference Interval
Test Number
Reference Interval
 von Willebrand MultimericNormal
0030095Factor VIII, Activity
AgeReference Interval
0-6 years56-191%
7-9 years76-199%
10-11 years80-209%
12-13 years72-198%
14-15 years69-237%
16-17 years63-221%
18 years and older56-191%

0030285von Willebrand Factor Antigen
AgeReference Interval
0-6 years52-214%
7-9 years62-180%
10-11 years63-189%
12-13 years60-189%
14-15 years57-199%
16-17 years50-205%
18 years and older52-214%

0030250von Willebrand Factor Activity (Ristocetin Cofactor)
AgeReference Interval
0-6 years51-215%
7-9 years52-176%
10-11 years60-195%
12-13 years50-184%
14-15 years50-203%
16-17 years49-204%
18 years and older51-215%

Interpretive Data

Compliance Statement D: For laboratory tests using a manufactured RUO kit. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Hotline History
CPT Code(s)
Component Test Code*Component Chart NameLOINC
0030003von Willebrand Multimeric32217-2
0030095Factor VIII, Activity3209-4
0030250von Willebrand Factor, Activity (RCF)6014-5
0030285von Willebrand Factor, Antigen27816-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Factor VIII
  • Factor VIII, Activity
  • RCF
  • Ristocetin Cofactor
  • von Willebrand Factor, Activity
  • von Willebrand Factor, Antigen
  • von Willebrand Multimeric
  • vW Activity
  • vW multimeric
  • vWAg
  • VWF:A
  • VWF:Rco