Desipramine, Serum or Plasma by Tandem Mass Spectrometry
Ordering Recommendation

Optimize drug therapy and monitor patient adherence. Test only measures desipramine concentration. If imipramine will be administered, order Imipramine and Desipramine, Serum or Plasma (0090157).

Quantitative Liquid Chromatography/Tandem Mass Spectrometry
Mon, Wed, Fri
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Serum Pre-dose (Trough) Draw - At a Steady State Concentration or Plasma Pre-dose (Trough) Draw - At a Steady State Concentration in Plain Red, Lavender (K2EDTA), Lavender (K3EDTA), or Pink (K2EDTA). 
Specimen Preparation
Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Whole blood. Gel Separator Tubes, Light Blue (Sodium Citrate), or Yellow (SPS or ACD Solution). 
Please indicate in the supplied fields:
1.  Dose - List drug amount and include the units of measure
2.  Route - List the route of administration (IV, oral, etc.)
3.  Dose Frequency - Indicate how often the dose is administered (per day, per week, as needed, etc.)
4.  Type of Draw - Indicate the type of blood draw (Peak, Trough, Random, etc.) 
Ambient: 5 days; Refrigerated: 2 weeks; Frozen: 6 months 
Reference Interval
Therapeutic Range:100-300 ng/mL
Toxic:Greater than 500 ng/mL

Interpretive Data
The therapeutic range is based on serum pre-dose (trough) draw at steady-state concentration. Toxic concentrations may cause anticholinergic effects, drowsiness and cardiac abnormalities.

Hotline History
CPT Code(s)
Component Test Code*Component Chart NameLOINC
2011488Desipramine Dose Frequency52810-9
2011489Desipramine Route45373-8
2011490Desipramine Type of Draw49049-0
2011491Desipramine Serum or Plasma3531-1
2011492Desipramine Dose4212-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
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