Risperidone and Metabolite, Serum or Plasma
Ordering Recommendation

Optimize drug therapy and monitor patient adherence. This test detects risperidone (parent) AND paliperidone (9-hydroxyrisperidone, metabolite). For paliperidone (9-hydroxyrisperidone) only, order Paliperidone, Serum or Plasma (2007949).

Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Mon, Wed, Sat
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Pre-dose (trough) draw - At steady state concentration. 
Lavender (EDTA), pink (K2EDTA) or plain red. 
Specimen Preparation
Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution). 
Ambient: 2 weeks; Refrigerated: 2 weeks; Frozen: 2 months 
Reference Interval
Therapeutic rangeNot well established
Total (Risperidone and Metabolite)20-60 ng/mL
Toxic rangeNot well established

Interpretive Data
Adverse effects to risperidone therapy may include headache, nausea, dizziness, tachycardia, orthostatic hypotension and dyskinesia.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Hotline History
View Hotline History
CPT Code(s)
Component Test Code*Component Chart NameLOINC
2007952Risperidone Serum/Plasma9393-0
20079539 OH Risperidone Serum/Plasma9383-1
2007954Total Risper/9 OH Risper9394-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
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