Beta-2 Glycoprotein 1 Antibodies, IgG, IgM and IgA
Ordering Recommendation

When antiphospholipid syndrome (APS) is strongly suspected, preferred panel is Beta-2 Glycoprotein 1 Antibodies, IgG and IgM (0050321).

Semi-Quantitative Enzyme-Linked Immunosorbent Assay
1-2 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Serum separator tube. 
Specimen Preparation
Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Plasma or other body fluids. Contaminated, hemolyzed, grossly icteric, or severely lipemic specimens. 
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) 
Reference Interval
Test NumberComponentsReference Interval
Beta-2 Glycoprotein 1 Antibody, IgG0-20 SGU
Beta-2 Glycoprotein 1 Antibody, IgM0-20 SMU
Beta-2 Glycoprotein 1 Antibody, IgA0-20 SAU

Interpretive Data
The persistent presence of IgG and/or IgM beta 2 glycoprotein I (B2GPI) antibodies (greater than 99th percentile) is a laboratory criterion for the diagnosis of antiphospholipid syndrome (APS). Persistence is defined as moderate or high levels of IgG and/or IgM B2GPI antibodies detected in two or more specimens drawn at least 12 weeks apart (J Throm Haemost. 2006;4:295-306). B2GPI results greater than 20 SGU (IgG) and/or SMU (IgM) are considered positive based on the cutoff values established for this test. International reference materials and consensus units for anti-B2GPI antibodies have not been established (Clin Chim Acta. 2012;413(1-2):358-60; Arthritis Rheum. 2012;64(1):1-10.). Strong clinical correlation is recommended for a diagnosis of APS. Low positive IgG and IgM B2GPI antibody levels should be interpreted in light of APS-specific clinical manifestations and/or other criteria phospholipid antibody tests.

Hotline History
Component Test Code*Component Chart NameLOINC
0050322B2Glycoprotein 1, IgG Antibody44448-9
0050323B2Glycoprotein 1, IgM Antibody44449-7
0050324B2Glycoprotein 1, IgA Antibody21108-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Anti-B2-Glycoprotein 1
  • Anti-B2-Glycoprotein I
  • Anti-B2-GP 1
  • Anti-B2-GP I
  • Anti-B2-GP1
  • Anti-B2-GPI
  • Anti-beta-2 glycoprotein 1
  • Anti-Beta-2-Glycoprotein I
  • Apolipoprotein H
  • B2-glycoprotein 1 antibodies
  • B2GP Antibodies
  • B2GP1
  • B2GPI IgG, IgM, IgA
  • Beta 2 GP1 Ab IgA
  • Beta 2 GP1 Ab IgG
  • Beta 2 GP1 Ab IgM
  • Beta 2GP1 Ab
  • Beta-2 Glycoprotein 1