Oligoclonal Bands in CSF and Serum
0081135
Ordering Recommendation
Use for assessment of multiple sclerosis. Detect unique IgG oligoclonal bands in cerebrospinal fluid (CSF) in conjunction with a matched serum specimen. Preferred test is Oligoclonal Band Profile (0080440).
Mnemonic
OLIGOB
Methodology
Qualitative Isoelectric Focusing/Electrophoresis
Performed
Sun-Sat
Reported
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
- Patient Preparation
- Collect
- CSF AND serum separator tube or plain red. Serum specimen should be drawn within 48 hours of CSF collection.
- Specimen Preparation
- Allow serum to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transport 1.5 mL CSF (Min: 0.7 mL) AND transfer 1 mL serum to an ARUP Standard Transport Tube (Min: 0.5 mL).
- Storage/Transport Temperature
- Refrigerated.
- Unacceptable Conditions
- Remarks
- Stability
- Ambient: 8 hours; Refrigerated: 1 week; Frozen: 1 year
Reference Interval
Effective August 6, 2012
| Test Number | Components | Reference Interval |
|---|---|---|
| 0081139 | Oligoclonal Bands, CSF | Negative |
| 2005461 | Oligoclonal Bands Number, CSF | 0 - 1 Bands |
| Interpretation | By report |
Interpretive Data
Note
Specimens must be assayed together for interpretation.
This test reports only the number of oligoclonal bands. A patient is considered positive for CSF oligoclonal bands if there are two or more bands in the CSF immunoglobulin region that are not present in the serum. In order to confirm local production of oligoclonal IgG in CSF, a matched serum sample is required. Oligoclonal bands present in CSF, but not in serum, indicate central nervous system production. Oligoclonal bands are performed using isoelectric focusing and immunofixation.
This test reports only the number of oligoclonal bands. A patient is considered positive for CSF oligoclonal bands if there are two or more bands in the CSF immunoglobulin region that are not present in the serum. In order to confirm local production of oligoclonal IgG in CSF, a matched serum sample is required. Oligoclonal bands present in CSF, but not in serum, indicate central nervous system production. Oligoclonal bands are performed using isoelectric focusing and immunofixation.
CPT Code(s)
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0081139 | Oligoclonal Bands, CSF | 48668-8 |
| 2005461 | Oligoclonal Bands Number, CSF | 49852-7 |
| 2005464 | Oligoclonal Bands Interpretation | 49293-4 |
Aliases
- CSF oligoclonal bands
- Oligoclonal Bands Only
- Oligoclonal IgG, CSF
- Oliogoclonal bands, CSF