Patient Preparation

 

Collect

Serum Separator Tube (SST). 

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer two 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.6 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. 

Storage/Transport Temperature

Refrigerated. 

Unacceptable Conditions

Other body fluids. Hemolyzed, icteric, or lipemic specimens. 

Remarks

Mark specimens plainly as "acute" or "convalescent." 

Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) 

Effective November 18, 2013

Test Number	Components	Reference Interval
0050170	Coccidioides Antibody by CF	Less than 1:2
0050183	Coccidioides immitis Antibodies by Immunodiffusion	None detected.
0050179	Coccidioides Antibody, IgG by ELISA	0.9 IV or less Negative - No significant level of Coccidioides IgG antibody detected. 1.0-1.4 IV Equivocal - Questionable presence of Coccidioides IgG antibody detected.  Repeat testing in 10-14 days may be helpful. 1.5 IV or greater Positive - Presence of IgG antibody to Coccidioides detected, suggestive of current or past infection.
0050178	Coccidioides Antibody, IgM by ELISA	0.9 IV or less Negative - No significant level of Coccidioides IgM antibody detected. 1.0-1.4 IV Equivocal - Questionable presence of Coccidioides IgM antibody detected.  Repeat testing in 10-14 days may be helpful. 1.5 IV or greater Positive - Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection.

Refer to report.

For Coccidioides, immunodiffusion (ID) measures IgM antibody, while complement fixation (CF) measures both IgG and IgM. ELISA tests can be used to detect both coccidioidal IgG and IgM antibodies. While elevated single antibody titers may be diagnostic, paired specimens are preferred. Acute and convalescent specimens (drawn at least 21 days apart), showing a fourfold or greater rise in titer, are diagnostic.

Negative fungal serology does not rule out the possibility of current infection.

View Hotline History

86635 x4

Component Test Code*	Component Chart Name	LOINC
0050170	Coccidioides Antibody by CF	33380-7
0050178	Coccidioides Antibody, IgM by ELISA
0050179	Coccidioides Antibody, IgG by ELISA	27009-0
0050183	Coccidioides immitis Abs, Precipitin	5095-5

* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

• Cocci Antibodies Panel
• COCCI CF,ID,ELISA
• Coccidioides Antibodies Serum panel
• San Joaquin Fever Antibodies
• Valley Fever Antibodies