Coccidioides Antibodies Panel, Serum by CF, ID, ELISA
0050588
Ordering Recommendation
Preferred serology test to detect coccidioidomycosis (Valley fever).
Mnemonic
COCCI PAN
Methodology
Semi-Quantitative Complement Fixation/Qualitative Immunodiffusion/Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun-Sat
Reported
2-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
- Patient Preparation
- Collect
- Serum Separator Tube (SST).
- Specimen Preparation
- Separate from cells ASAP or within 2 hours of collection. Transfer two 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.6 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens.
- Storage/Transport Temperature
- Refrigerated.
- Unacceptable Conditions
- Other body fluids. Hemolyzed, icteric, or lipemic specimens.
- Remarks
- Mark specimens plainly as "acute" or "convalescent."
- Stability
- After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval
Effective November 18, 2013
Test Number | Components | Reference Interval | ||||||
---|---|---|---|---|---|---|---|---|
0050170 | Coccidioides Antibody by CF | Less than 1:2 | ||||||
0050183 | Coccidioides immitis Antibodies by Immunodiffusion | None detected. | ||||||
0050179 | Coccidioides Antibody, IgG by ELISA |
| ||||||
0050178 | Coccidioides Antibody, IgM by ELISA |
|
Interpretive Data
Refer to report.
Note
For Coccidioides, immunodiffusion (ID) measures IgM antibody, while complement fixation (CF) measures both IgG and IgM. ELISA tests can be used to detect both coccidioidal IgG and IgM antibodies. While elevated single antibody titers may be diagnostic, paired specimens are preferred. Acute and convalescent specimens (drawn at least 21 days apart), showing a fourfold or greater rise in titer, are diagnostic.
Negative fungal serology does not rule out the possibility of current infection.
Negative fungal serology does not rule out the possibility of current infection.
Hotline History
View Hotline History
CPT Code(s)
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0050170 | Coccidioides Antibody by CF | 33380-7 |
0050178 | Coccidioides Antibody, IgM by ELISA | |
0050179 | Coccidioides Antibody, IgG by ELISA | 27009-0 |
0050183 | Coccidioides immitis Abs, Precipitin | 5095-5 |
Aliases
- Cocci Antibodies Panel
- COCCI CF,ID,ELISA
- Coccidioides Antibodies Serum panel
- San Joaquin Fever Antibodies
- Valley Fever Antibodies