3001501
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CYP2C8, CYP2C9, and CYP2C cluster

2C8/2C9
Example Reports
Negative
Positive

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Informed Consent for Genetic Testing (Required for NY patients)

Ordering Recommendation

Use to assess genetic risk of abnormal drug metabolism for drugs metabolized by enzymes coded by CYP2C8, CYP2C9, and the 2C cluster variant (rs12777823).

May aid in drug selection and dose planning for drugs metabolized by enzymes coded by CYP2C8, CYP2C9 and the 2C cluster variant (rs12777823).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Lavender (EDTA), pink (K2EDTA), or yellow (ACD solution A or B).

Specimen Preparation

Transport 3 mL whole blood. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma or serum. Specimens collected in sodium heparin or lithium heparin. Frozen specimens in glass collection tubes.

Remarks
Stability

Ambient: 72 hours; Refrigerated: 1 week; Frozen: 1 month

Methodology

Polymerase Chain Reaction (PCR)/Fluorescence Monitoring

Performed

Varies

Reported

5-10 days

Reference Interval

By report

Interpretive Data

Refer to report

Compliance Category

Laboratory Developed Test (LDT)

Note

Whole blood is the preferred specimen. Saliva samples that yield inadequate DNA quality and/or quantity will be reported as inconclusive if test performance does not meet laboratory-determined criteria for reporting.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
11/13/2023
X
X
05/15/2023
X
N/A

CPT Codes

81227; 81479

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Components

Component Test Code* Component Chart Name LOINC
2008931 CYP2C9 Phenotype 79716-7
3001502 2C8/2C9 Specimen 66746-9
3001503 CYP2C8 Genotype 78972-7
3001504 CYP2C9 Genotype 46724-1
3001505 2C8/2C9 Interpretation 50398-7
3004497 CYP2C8 Phenotype 81259-4
3004499 CYP2C Cluster Geno 101785-4
3004500 CYP2C Cluster Pheno 81259-4
3016871 EER CYP2C8 CYP2C9 CYP2C Cluster 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • 2C8
  • 2C9
  • celecoxib
  • Coumadin
  • CYP2C8
  • CYP2C9
  • CYP2C9 cluster
  • Cytochrome P450 2C8
  • Cytochrome P450 2C9 Genotype
  • flurbiprofen
  • glibenclamide
  • gliclazide
  • glimepiride
  • ibuprofen
  • lornoxicam
  • Mayzent
  • meloxicam
  • NSAIDS
  • phenytoin
  • piroxicam
  • siponimod
  • sulfonylureas
  • tenoxicam
  • tolbutamide
  • warfarin
CYP2C8, CYP2C9, and CYP2C cluster