Search our extensive Laboratory Test Directory to find test codes, ordering recommendations, specimen stability information, Test Fact Sheets, and more.
Recommendations when to order or not order the test. May include related or preferred tests.
Supports clinical diagnosis of Alzheimer's disease (AD) in symptomatic individuals; for AD risk assessment only. Use to assess risk of amyloid-related imaging abnormalities (ARIA) when prescribing amyloid-targeted antibody treatments (e.g., lecanemab, donanemab). Pre- and post-test genetic counseling strongly recommended for informed consent and discussion of results.
New York DOH Approval Status
Indicates whether a test has been approved by the New York State Department of Health.
This test is New York state approved.
Specimen Required
Patient PreparationInstructions patient must follow before/during specimen collection.
CollectSpecimen type to collect. May include collection media, tubes, kits, etc.
Lavender (EDTA), pink (K2EDTA), or yellow (ACD solution A or B).
Specimen PreparationInstructions for specimen prep before/after collection and prior to transport.
Transport 3 mL whole blood. (Min: 1 mL)
Storage/Transport TemperaturePreferred temperatures for storage prior to and during shipping to ARUP. See Stability for additional info.
Refrigerated.
Unacceptable ConditionsCommon conditions under which a specimen will be rejected.
Plasma or serum. Heparinized specimens. Frozen specimens in glass collection tubes.
RemarksAdditional specimen collection, transport, or test submission information.
Testing of fetal specimens or specimens from patients under the age of 18 years is not offered.
StabilityAcceptable times/temperatures for specimens. Times include storage and transport time to ARUP.
Expected turnaround time for a result, beginning when ARUP has received the specimen.
2-7 days
Reference Interval
Normal range/expected value(s) for a specific disease state. May also include abnormal ranges.
Refer to report
Interpretive Data
May include disease information, patient result explanation, recommendations, or details of testing.
Refer to Report
Counseling and informed consent are recommended for genetic testing. Consent forms are available online.
Compliance Category
Laboratory Developed Test (LDT)
Note
Additional information related to the test.
Hotline History
N/A
CPT Codes
The American Medical Association Current Procedural Terminology (CPT) codes published in ARUP's Laboratory Test Directory are provided for informational purposes only. The codes reflect our interpretation of CPT coding requirements based upon AMA guidelines published annually. CPT codes are provided only as guidance to assist clients with billing. ARUP strongly recommends that clients confirm CPT codes with their Medicare administrative contractor, as requirements may differ. CPT coding is the sole responsibility of the billing party. ARUP Laboratories assumes no responsibility for billing errors due to reliance on the CPT codes published.
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
Other names that describe the test. Synonyms.
Alzheimer's
Alzheimers
APOE E4
ApoE 2 variants
ApoE Alzheimer Risk
ApoLipoprotein E Genotype
Lecanemab
Leqembi
ARIA
Donanemab
Kisunla
Apolipoprotein E (APOE) Genotyping, Alzheimer Disease Risk
Connect Sign In
