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Chromosome Analysis, Constitutional Blood, with Reflex to Genomic Microarray
Ordering Recommendation
Appropriate when there is a significant chance of trisomy. Chromosome studies will identify obvious numerical abnormalities, balanced chromosomal rearrangements, and large deletions/duplications. If chromosomes are normal, then testing reflexes to microarray.
New York DOH Approval Status
Specimen Required
Green (sodium heparin).
New York State Clients: Lavender (EDTA) AND Green (sodium heparin)
Do not freeze or expose to extreme temperatures. Transport 5 mL whole blood. (Min: 2 mL)
New York State Clients: Transport 3 mL whole blood EDTA (Min: 2 mL) AND 4 mL whole blood (sodium heparin) (Min: 2 mL)
FOR NEW YORK CLIENT NEWBORNS: 1 mL whole blood EDTA (Min: 1 mL) AND 4 mL whole blood (sodium heparin) (Min: 2 mL)
Room temperature.
Frozen specimens. Clotted specimens.
New York State Clients: Testing is only approved for Chromosome Analysis. Reflex testing will referred.
Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable
New York State Clients: Ambient: 1 week; Refrigerated: 1 week; Frozen: Unacceptable
Methodology
Giemsa Band/Genomic Microarray (Oligo-SNP Array)
Performed
Sun-Sat
Reported
3-10 days
If reflexed, add 7-12 days.
Reference Interval
By report
Interpretive Data
Refer to report.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Counseling and informed consent are recommended for genetic testing. Consent forms are available online.
Laboratory Developed Test (LDT)
Note
These studies involve culturing of living cells; therefore, turnaround times given represent average times, which are subject to multiple variables.
A processing fee will be charged if the client cancels this procedure after the test has been set up
When the result of Chromosome Analysis is "normal," then Genomic Microarray testing will be added. Additional charges apply.
Specimen and completed test request form, including clinical indication, must be received within 48 hours of collection.
Testing on a neonate, 7 days old or younger, will automatically order a preliminary chromosome analysis (intended to identify whole chromosome aneuploidies and large structural rearrangements). This will be reported under the same accession number as the final chromosome report, and is generally available in 2-3 days, if sample quantity and metaphase quality permits. Final results will be available within 5-7 days.
This test must be ordered using Cytogenetic test request form #43097 or through your ARUP interface. Please submit the Patient History for Pediatric/Adult Cytogenetic (Chromosome) Studies form with the electronic packing list (https://ltd.aruplab.com/Tests/Pdf/20).
Hotline History
CPT Codes
88262; 88230; if reflexed, add 81229
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0097640 | Chromosome Analysis Constitutional Blood | 29770-5 |
| 2006186 | EER Chrom Analysis PB w/Rflx to Array | 11526-1 |
Aliases
- aCGH
- array
- Array CGH
- Array Comparative Genomic Hybridization
- CGH
- Chromosomal Microarray
- CMA
- CMA SNP
- Comparative Genomic Hybridization
- Congenital Array
- Constitutional Array
- Microarray
- Molecular Karyotype
- Oligo Array
- oligoarray
- Oligonucleotide Array
- Single-nucleotide-polymorphism (SNP) array
- Targeted Array
- Whole Genome Array
