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Myeloproliferative Disorders Panel by FISH
Ordering Recommendation
Limited role in the workup of myeloproliferative neoplasms in the setting of an otherwise optimal cytogenetic study. Aids in exclusion of cryptic BCR-ABL1 rearrangement in chronic myelogenous leukemia and in the exclusion of a PDGFRA abnormality in cases of neoplastic eosinophilia.
New York DOH Approval Status
Specimen Required
Nondiluted bone marrow collected in a heparinized syringe. Also acceptable: Green (sodium heparin) tube.
Transfer 3 mL bone marrow to a green (sodium heparin) (Min: 1 mL). OR transport 5 mL whole blood (Min: 2 mL).
Room temperature.
Frozen specimens. Paraffin-embedded specimens. Clotted specimens.
Clinical indication or reason for testing and specimen type required with test order. Sample will still be processed if this information is not initially provided but appropriate culturing and reporting may be compromised or delayed.
Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable
Methodology
Fluorescence in situ Hybridization (FISH)
Performed
Sun-Sat
Reported
3-9 days
Reference Interval
Refer to report
Interpretive Data
Probes included: BCR/ABL, PDGFR-alpha, PDGFR-beta, and, FGFR1.
Analyte Specific Reagent (ASR)
Note
A processing fee will be charged if this procedure is canceled, at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow culture growth. The fee will vary based on specimen type.
Other specimen types may be acceptable, contact the Cytogenetics Laboratory for specific specimen collection and transportation instructions.
If cell pellets or dropped cytogenetics slides are not submitted, a processing fee will apply.
This test must be ordered using Oncology test request form #43099 or through your ARUP interface.
If chromosome analysis is not performed at ARUP on the same sample, Bone Marrow/PBL Culture Processing Fee (0093271) will be added to account for sample processing, and additional charge will apply. If multiple FISH tests are ordered, 0093271 will only be applied to one of the FISH tests.
Hotline History
CPT Codes
88271 x4; 88275 x4
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2002361 | MPD Panel by FISH | |
| 2002362 | EER FISH MPD P |
