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Chromosome FISH, Interphase
Ordering Recommendation
Use to order individual or multiple oncology FISH probes if standard FISH panels are not desired.
New York DOH Approval Status
Specimen Required
Non-diluted bone marrow aspirate collected in a heparinized syringe. Also acceptable: Green (sodium heparin).
Transfer 3 mL bone marrow to a green (sodium heparin) (Min: 1 mL). OR transport 5 mL whole blood (Min: 2 mL)
Room temperature.
Paraffin-embedded specimens. Clotted specimens.
Desired FISH probe and pertinent clinical diagnosis required with test order. Testing will not be performed until probe and diagnosis are provided; absence of this information will delay turnaround time.
Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable
Methodology
Fluorescence in situ Hybridization (FISH)
Performed
Sun-Sat
Reported
3-10 days
Reference Interval
By report
Interpretive Data
Laboratory Developed Test (LDT)
Note
Time required for testing can vary depending on specimen type and probes ordered.
Please indicate the names of probes needed for testing. Molecular Cytogenetics (FISH) Probe menu is available at https://www.aruplab.com/genetics/tests/fish-oncology
Contact ARUP Genetics Processing at extension 3301 to add a probe to a current specimen.
Other specimen types may be acceptable, contact the Cytogenetics Laboratory for specific specimen collection and transportation instructions.
If cell pellets or dropped cytogenetic slides are submitted, processing fee will not apply.
This test must be ordered using Oncology test request form #43099 or through your ARUP interface.
Hotline History
CPT Codes
88271; 88275
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0092615 | Chromosome FISH, Interphase | 57802-1 |
| 2002196 | EER Chromosome FISH, Interphase | 11526-1 |
Aliases
- RUNX1T1-RUNX1 (ETO-AML1) Fusion
- PML-RARA Fusion
- ETV6-RUNX1 (TEL-AML1 ) Fusion
- TCL1 Rearrangement
- t(14;20)(q32;q12)
- ETV6 Rearrangement
- ABL1 Rearrangement
- ABL2 Rearrangement
- EPOR Rearrangement
- CSF1R Rearrangement
- RPN1/MECOM (EVI1)
- EGR1
- inv(3)
- t(3:3)
- MALT1
- 18q21
- CKS1B
- 1q21
- +9
- Trisomy 17
- NUP98 Rearrangement
- CBFB-MYH11 Fusion, t(16;16)(p13.1;q22)
- del(11)(q22.3)
- +12
- ATM Deletion
- Trisomy 12
- D13S319 Deletion
- TP53 (p53) Deletion
- PDGFRB, 5q33.1
- FGFR1, 8p11-12
- IKZF1 (Ikaros) Deletion
- JAK2 Rearrangement
- +10
- +17
- 5q32
- 9p21
- t(15;17)(q24;q21)
- oncology FISH
- t(11;14)(q13;q32)
- +4
- del(13)(q14.3)
- 8p12
- Trisomy 15
- RUNX1 Rearrangement
- 21q22
- IGH-FGFR3 Fusion
- 7q Deletion(D7S486)/Monosomy 7
- 19p13
- t(8;21)(q22;q22)
- inv(16)(p13.3q22)
- 8q24
- X and Y centromere (CEP X/Y)
- p16 (CDKN2) Deletion
- IGH Rearrangement
- IGH-MAFB Fusion
- TCF3 (E2A) Rearrangement
- Trisomy 4
- +15
- BCR-ABL1
- IGH-MAF Fusion
- 5q33.1
- KMT2A (MLL) Rearrangement
- 5q Deletion (EGR1)/Monosomy 5
- t(9;22)(q34;q11.2)
- t(12;21)(p13;q22)
- 11q23
- 14q32
- CBFB Rearrangement
- IGH-CCND1 Fusion
- inv(16)
- 3q27
- t(14;18)(q32;q21)
- C-Myc (MYC) Rearrangement
- BCL6 Rearrangement
- 20q Deletion (D20S108)
- del(5)(q31)/-5
- del(7)(q31)/-7
- +8
- del(20)(q12)
- t(4;14)(p16;q32)
- PDGFRA Rearrangement
- del(17)(p13.1) (TP53) Deletion
- PDGFR-alpha Rearrangement
- PDGFRB Rearrangement
- 22q12.2
- EWSR1 Rearrangement
- Trisomy 8
- PDGFR-beta Rearrangement
- FGFR1 Rearrangement
- Trisomy 10
- CRLF2 Rearrangement
- PDGFRA-CHIC2-FIP1L1
- Trisomy 9
- Cancer FISH
- Philadelphia chromosome
- Hyperdiploidy with Trisomy 4, 10, and 17
- 4q12
- IGH-BCL2 Fusion
- t(14;16)(q32;q23.1)
