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Chromosome FISH, Interphase
Ordering Recommendation
Use to order individual or multiple oncology FISH probes if standard FISH panels are not desired.
New York DOH Approval Status
Specimen Required
Non-diluted bone marrow aspirate collected in a heparinized syringe. Also acceptable: Green (sodium heparin).
Transfer 3 mL bone marrow to a green (sodium heparin) (Min: 1 mL). OR transport 5 mL whole blood (Min: 2 mL)
Room temperature.
Paraffin-embedded specimens. Clotted specimens.
Desired FISH probe and pertinent clinical diagnosis required with test order. Testing will not be performed until probe and diagnosis are provided; absence of this information will delay turnaround time.
Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable
Methodology
Fluorescence in situ Hybridization (FISH)
Performed
Sun-Sat
Reported
3-10 days
Reference Interval
By report
Interpretive Data
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
Time required for testing can vary depending on specimen type and probes ordered.
Please indicate the names of probes needed for testing. Molecular Cytogenetics (FISH) Probe menu is available at https://www.aruplab.com/Testing-Information/resources/FISH_probes/fish_probes_oncology.pdf
Contact ARUP Genetics Processing at extension 3301 to add a probe to a current specimen.
Other specimen types may be acceptable, contact the Cytogenetics Laboratory for specific specimen collection and transportation instructions.
If cell pellets or dropped cytogenetic slides are submitted, processing fee will not apply.
This test must be ordered using Oncology test request form #43099 or through your ARUP interface.
Hotline History
CPT Codes
88271; 88275
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0092615 | Chromosome FISH, Interphase | 57802-1 |
| 2002196 | EER Chromosome FISH, Interphase | 11526-1 |
Aliases
- IGH-MAF Fusion
- del(7)(q31)/-7
- EGR1
- EPOR Rearrangement
- ETV6 Rearrangement
- ETV6-RUNX1 (TEL-AML1 ) Fusion
- EWSR1 Rearrangement
- PDGFRB Rearrangement
- CBFB-MYH11 Fusion, t(16;16)(p13.1;q22)
- CKS1B
- +17
- +4
- KMT2A (MLL) Rearrangement
- 11q23
- oncology FISH
- p16 (CDKN2) Deletion
- IGH-BCL2 Fusion
- IGH-CCND1 Fusion
- 5q32
- 7q Deletion(D7S486)/Monosomy 7
- t(14;16)(q32;q23.1)
- t(14;18)(q32;q21)
- TP53 (p53) Deletion
- C-Myc (MYC) Rearrangement
- Cancer FISH
- CBFB Rearrangement
- CSF1R Rearrangement
- 12q31
- JAK2 Rearrangement
- Trisomy 8
- Trisomy 9
- t(8;21)(q22;q22)
- Trisomy 10
- Trisomy 12
- Trisomy 15
- Trisomy 17
- Trisomy 4
- X and Y centromere (CEP X/Y)
- t(3:3)
- +10
- +12
- +15
- MALT1
- NUP98 Rearrangement
- 19p13
- SS18 (SYT) Rearrangement
- t(11;14)(q13;q32)
- t(4;14)(p16;q32)
- t(9;22)(q34;q11.2)
- inv(16)
- D13S319 Deletion
- DDIT3 (CHOP)
- del(11)(q22.3)
- BCL6 Rearrangement
- BCR-ABL1
- 13q13
- 8p12
- 8q24
- inv(3)
- ATM Deletion
- Hyperdiploidy with Trisomy 4, 10, and 17
- CRLF2 Rearrangement
- PDGFRB, 5q33.1
- Philadelphia chromosome
- PML-RARA Fusion
- RPN1/MECOM (EVI1)
- RUNX1 Rearrangement
- t(14;20)(q32;q12)
- t(15;17)(q24;q21)
- del(20)(q12)
- del(5)(q31)/-5
- t(12;21)(p13;q22)
- inv(16)(p13.3q22)
- TCF3 (E2A) Rearrangement
- TCL1 Rearrangement
- IGH Rearrangement
- 20q Deletion (D20S108)
- ABL1 Rearrangement
- 14q32
- 18q11.2
- 5q Deletion (EGR1)/Monosomy 5
- 18q21
- FGFR1 Rearrangement
- FGFR1, 8p11-12
- 1q21
- FKHR (FOXO1)
- PDGFR-alpha Rearrangement
- PDGFR-beta Rearrangement
- 21q22
- 3q27
- 22q12.2
- IGH-MAFB Fusion
- IKZF1 (Ikaros) Deletion
- RUNX1T1-RUNX1 (ETO-AML1) Fusion
- 5q33.1
- del(13)(q14.3)
- del(17)(p13.1) (TP53) Deletion
- IGH-FGFR3 Fusion
- PDGFRA Rearrangement
- PDGFRA-CHIC2-FIP1L1
- +8
- +9
- 4q12
- 9p21
- ABL2 Rearrangement
