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PZA testing is discontinued by the manufacturer. ARUP will continue to test the other first-line drugs: rifampin, isoniazid, and ethambutol. If PZA susceptibility testing is requested, contact your local public health laboratory or the CDC for pncA gene testing for PZA resistance mutations.
Recommendations when to order or not order the test. May include related or preferred tests.
If PZA susceptibility testing is requested for M. tuberculosis complex isolates, contact your local public health laboratory or the CDC for pncA gene testing for PZA resistance mutations. ARUP performs testing for other first-line drugs: rifampin, isoniazid, and ethambutol.
New York DOH Approval Status
Indicates whether a test has been approved by the New York State Department of Health.
This test is New York state approved.
Specimen Required
Patient PreparationInstructions patient must follow before/during specimen collection.
CollectSpecimen type to collect. May include collection media, tubes, kits, etc.
Actively growing isolate of Mycobacterium tuberculosis in pure culture.
Specimen PreparationInstructions for specimen prep before/after collection and prior to transport.
Transport sealed container with pure culture on solid or liquid media. Place each specimen in an individually sealed bag.
Storage/Transport TemperaturePreferred temperatures for storage prior to and during shipping to ARUP. See Stability for additional info.
Room temperature. Submit specimen according to Infectious Substance, Category A, shipping guidelines.
Unacceptable ConditionsCommon conditions under which a specimen will be rejected.
Mixed cultures or non-viable organisms. Organisms submitted on agar plate.
RemarksAdditional specimen collection, transport, or test submission information.
StabilityAcceptable times/temperatures for specimens. Times include storage and transport time to ARUP.
Expected turnaround time for a result, beginning when ARUP has received the specimen.
21-28 days
Reference Interval
Normal range/expected value(s) for a specific disease state. May also include abnormal ranges.
By report
Interpretive Data
May include disease information, patient result explanation, recommendations, or details of testing.
The interpretation provided is based on results for the following drugs at the stated concentrations: Drugs tested: Ethambutol: 5.0 ug/mL, isoniazid: 0.1 ug/mL (0.4 ug/mL if resistant to 0.1 ug/mL), and rifampin: 1.0 ug/mL.
This procedure screens isolates of M. tuberculosis complex for drug resistance. The procedure does not use serial dilutions to provide quantitative MIC values. Single critical concentrations for each antimycobacterial agent used have been defined by the United States Public Health Service.
Compliance Category
FDA
Note
Additional information related to the test.
Hotline History
N/A
CPT Codes
The American Medical Association Current Procedural Terminology (CPT) codes published in ARUP's Laboratory Test Directory are provided for informational purposes only. The codes reflect our interpretation of CPT coding requirements based upon AMA guidelines published annually. CPT codes are provided only as guidance to assist clients with billing. ARUP strongly recommends that clients confirm CPT codes with their Medicare administrative contractor, as requirements may differ. CPT coding is the sole responsibility of the billing party. ARUP Laboratories assumes no responsibility for billing errors due to reliance on the CPT codes published.
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
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