Ordering Recommendation

Recommended for the differential diagnosis of SLE and Sjogren syndrome. Preferred panel contains SSA 52, SSA 60, and SSB; refer to Extractable Nuclear Antigen Antibodies (SSA 52, SSA 60, and SSB) (0050791).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.2 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma or other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Methodology

Semi-Quantitative Multiplex Bead Assay

Performed

Sun-Sat

Reported

1-3 days

Reference Interval

Test Number
Components
Reference Interval
  SSB (La) (ENA) Antibody, IgG 40 AU/mL or less

Interpretive Data

SSB (La) antibody is seen in 50-60% of Sjögren syndrome cases and is specific if it is the only ENA antibody present. Fifteen-25% of patients with systemic lupus erythematosus (SLE) and 5-10% of patients with progressive systemic sclerosis (PSS) also have this antibody.


Component
Interpretation
SSB (La) (ENA) Antibody, IgG 29 AU/mL or less            Negative
30-40 AU/mL                   Equivocal
41 AU/mL or greater      Positive

Compliance Category

FDA

Note

Hotline History

N/A

CPT Codes

86235

Components

Component Test Code* Component Chart Name LOINC
0050692 SSB (La) (ENA) Antibody, IgG 29965-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • anti-Sjögren Syndrome B
  • anti-SSB
  • Anti-SSB (La) (ENA) Antibody
  • Sjogren's Antibody
  • SSB (La)
SSB (La) (ENA) Antibody, IgG