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MYD88 L265P Mutation Detection, Tissue, by PCR, Quantitative

MYD88TISS

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Additional Technical Information

Ordering Recommendation

Useful in distinguishing lymphoplasmacytic lymphoma (LPL) from other low-grade B-cell lymphoproliferative disorders which may be in the differential diagnosis. Use when monitoring patients with LPL diagnosis and previously identified MYD88 L265P mutation.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Fresh tissue or formalin-fixed tumor tissue.

Specimen Preparation

FFPE Tumor Tissue : Formalin-fixed (10 percent neutral buffered formalin) and paraffin-embedded tissue. Protect from excessive heat. Transport tissue in a tissue transport kit (ARUP Supply #47808) available online through eSupply using ARUP Connect(TM) or contact ARUP Client Services at 800-522-2787.

Storage/Transport Temperature

FFPE Tumor Tissue : Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.

Unacceptable Conditions

FFPE Tumor Tissue: Specimens fixed in any fixative other than 10 percent neutral buffered formalin.

Remarks

If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.

Stability

FFPE Tumor Tissue: Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Methodology

Quantitative Real-Time Polymerase Chain Reaction

Performed

Varies

Reported

8-13 days

Reference Interval

Interpretive Data

Refer to report.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
10/19/2026
X
N/A

CPT Codes

81305

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Components

Component Test Code* Component Chart Name LOINC
3021232 MYD88 L268P Tiss, Quant
3021233 MYD88 L268P Tiss, Rslt 82140-5
3021234 MYD88 Tissue Source 31208-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Lymphoplasmacytic lymphoma
  • Waldenstrom macroglobulinemia
MYD88 L265P Mutation Detection, Tissue, by PCR, Quantitative