3020918
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Anti-Beta-2 Glycoprotein 1 Domain 1, IgG

B2GP1-D1

Ordering Recommendation

Use as part of the laboratory workup for antiphospholipid syndrome (APS) when criteria antibodies (anti-cardiolipin and anti-beta2 glycoprotein 1 IgG/IgM) are of low titers or undetectable.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube (SST) or citrated plasma

Specimen Preparation

Separate serum or plasma from cells as soon as possible or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP standard transport tube. (Min: 0.3 mL)

Storage/Transport Temperature

Refrigerated (2-8 degrees C).

Unacceptable Conditions

Contaminated, heat-inactivated, clots, fibrin, gross red blood cells, severely lipemic, severely hemolyzed, or severely icteric specimens.

Remarks
Stability

After separation from cells:
Room temperature: 48 hours
Refrigerated: 2 weeks
Frozen: 30 days (avoid repeated freeze-thaw cycles, but up to 3 freeze-thaw cycles is acceptable)

Methodology

Semi-Quantitative Chemiluminescent Immunoassay (CLIA)

Performed

Mon, Wed, Fri

Reported

1-5 days

Reference Interval

Test Number
 Components
 Reference Interval
  B2Glycoprotein 1 Domain 1, IgG Antibody 0.0-19.9 CU: Negative

Interpretive Data

  IgG autoantibodies to the domain-1 of the beta-2 glycoprotein protein (anti-B2GP1-D1) are a subset of anti-B2GP1 antibodies that have been linked to thrombotic and/or obstetric complications in individuals with antiphospholipid syndrome (APS). Anti-B2GP1-D1 antibodies have been found to be of high specificity for APS diagnosis. Note that anti-B2GP1-D1 are not included in the ACR/EULAR APS classification criteria.

Compliance Category

FDA

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
07/20/2026
X
N/A

CPT Codes

86146

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Components

Component Test Code* Component Chart Name LOINC
3020920 B2Glycoprotein 1 Domain 1, IgG Antibody
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Aliases

  • Anti-B2-glycoprotein 1 domain 1
  • B2-glycoprotein 1 domain 1
  • Anti-Beta-2-glycoprotein 1 domain 1
  • Beta-2-glycoprotein 1 domain 1
  • Anti-Domain 1 Beta-2 Glycoprotein 1
  • Beta 2 GP1 domain 1 Ab IgG
  • Beta 2GP1 domain 1 Ab
  • Anti-B2GP 1 domain 1
Anti-Beta-2 Glycoprotein 1 Domain 1, IgG