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Kappa Free Light Chains, CSF
Ordering Recommendation
Used to assess for multiple sclerosis and other inflammatory central nervous system (CNS) diseases. This test is a quantitative alternative to the oligoclonal band assay.
A reflexive panel, CSF Kappa Free Light Chains With Reflex to Oligoclonal Banding (3021031), is also available. It screens for the presence of cerebrospinal fluid (CSF) kappa free light chains and reflexes to oligoclonal band testing when results are borderline or positive.
New York DOH Approval Status
Specimen Required
CSF
Transfer 1 mL CSF to an ARUP standard transport tube (Min: 0.5 mL)
Frozen
Grossly bloody or hemolyzed specimens.
Ambient: 48 hours; Refrigerated: 14 days; Frozen: 30 days
Methodology
Quantitative Immunoturbidimetry
Performed
Mon, Wed, Fri
Reported
1-4 days
Reference Interval
| Test Number |
Components |
Reference Interval |
|---|---|---|
| Kappa Free Light Chains, CSF | Less than 0.33 mg/L |
Interpretive Data
Results between 0.33 and 1.09 mg/L are considered equivocal, while results greater than or equal to 1.10 mg/L are considered positive. These findings reflect CSF-specific immunoglobulin synthesis. They are not specific for multiple sclerosis and may also be detected in patients with other neurologic diseases (autoimmune, infectious, inflammatory, cerebrovascular, and paraneoplastic). Consider additional CSF testing such as oligoclonal banding if clinically indicated.
| Negative: | Less than 0.33 mg/L |
| Equivocal: | 0.33 mg/L-1.09 mg/L |
| Positive: | Greater than 1.09 mg/L |
Laboratory Developed Test (LDT)
Note
Hotline History
Hotline History
CPT Codes
83521
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 3021029 | Kappa Free Light Chains, CSF | 48774-4 |
Aliases
- cerebrospinal fluid
- Kappa Free Light Chain, spinal fluid
- Free Light Chain, cerebrospinal fluid
- Free Light Chain, spinal fluid
- Cerebrospinal fluid Free Light Chain
- Spinal fluid Free Light Chain
- Multiple Sclerosis
- MS
- Oligoclonal Banding
