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Tropical Fever Panel by PCR
Ordering Recommendation
Use to rapidly detect a panel of common viruses, bacteria, and parasites associated with acute febrile illness or recent acute febrile illness and known exposure to the target pathogens.
Evaluation for more common causes of acute febrile illness (e.g., infections of the upper and lower respiratory tract or gastroenteritis, as well as noninfectious causes) should be considered prior to evaluation with this panel. Results are meant to be used in conjunction with other clinical, epidemiologic, and laboratory data, in accordance with the guidelines provided by the relevant public health authorities.
This test is not intended for screening asymptomatic individuals.
New York DOH Approval Status
Specimen Required
N/A
Minimum 0.5 ml human whole blood collected in EDTA tubes
Collect blood in EDTA blood tube
Refrigerated
Frozen
The panel detects and identifies selected bacterial, viral, and parasitic nucleic acids directly from EDTA whole blood collected from individuals with signs and/or symptoms of acute febrile illness or recent acute febrile illness and known or suspected exposure to the following target pathogens: chikungunya virus, dengue virus (serotypes 1, 2, 3 and 4), Leptospira spp., and Plasmodium spp. (including species differentiation of Plasmodium falciparum and Plasmodium vivax / ovale ).
Ambient: 24 hours
Refrigerated: Up to 7 days
Methodology
Qualitative Polymerase Chain Reaction (PCR)
Performed
Sun-Sat
Reported
1-3 days
All Plasmodium spp. "Detected" results from patients potentially exposed in Southeast Asia should be further investigated for possible P. knowlesi infection, which may require intensive immediate monitoring and treatment.
Reference Interval
Interpretive Data
FDA
Note
This panel is not intended to be used as the sole basis for diagnosis, treatment, or other management decisions. Positive results do not rule out coinfection with other organisms not included on the panel, nor do negative results rule out infection. Negative results from the panel may require additional testing if clinically indicated. Not all pathogens that cause acute febrile illness are detected by this test, and negative results do not rule out the presence of other infections.
Patient travel history, exposure risk, and consultation of the CDC Yellow Book should be considered prior to use of this panel as some pathogens are more common in certain geographical locations.
A Plasmodium spp. "Detected" result does not provide parasitemia level information. The potential for severe malaria should be considered.
A dengue virus "Detected" result does not provide information on the severity of the disease. The potential for hemorrhagic dengue fever should be considered.
Performance of the test has not been established for monitoring treatment of malaria, dengue fever, chikungunya fever, or leptospirosis.
Hotline History
Hotline History
CPT Codes
0595U
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 3020831 | Leptospira spp. | 101302-8 |
| 3020832 | Chikungunya virus | 101303-6 |
| 3020833 | Dengue virus | 101304-4 |
| 3020834 | Plasmodium spp. | 101305-1 |
| 3020835 | Plasmodium Falciparum | 101306-9 |
| 3020836 | Plasmodium vivax/ovale | 101307-7 |
