Ordering Recommendation

Glutamate dehydrogenase (GDH) antigen and toxin A/B EIA testing for suspected Clostridioides (Clostridiumdifficile infection. This test does not reflex to nucleic acid amplification testing (NAAT), such as polymerase chain reaction (PCR).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Liquid or soft stool.

Specimen Preparation

Transfer 1.0 mL stool to a clean, unpreserved transport vial (ARUP Supply# 40910). Available online through eSupply using ARUP Connect(TM) or contact ARUP Client Services at 800-522-2787. (Min: 0.5 mL).

Storage/Transport Temperature

Refrigerated. Also acceptable: Frozen.

Unacceptable Conditions

Specimens preserved in Cary Blair/C&S media, formalin-based fixative (eg, formalin, SAF) or alcohol-based fixative (e.g., PVA, Totalfix, Alcorfix, etc). Formed stool.

Remarks
Stability

Ambient 2 hours; Refrigerated 72 hours; Frozen 1 week

Methodology

Qualitative Enzyme Immunoassay (EIA)

Performed

Sun-Sat

Reported

Within 24 hours

Reference Interval

Test Number
Components
Reference Interval
  Toxigenic C. difficile Interpretation Not Detected

Interpretive Data

  This test is intended for symptomatic patients with greater or equal to3 unformed stools in 24 hours . Testing of formed stool, asymptomatic patients, or for test of cure is not recommended. Results should always be interpreted in conjunction with clinical findings.

Compliance Category

FDA

Note

Hotline History

N/A

CPT Codes

87324; 87899

Components

Component Test Code* Component Chart Name LOINC
3001805 Toxigenic C. difficile Interpretation 34712-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • C diff
  • C diff antigen
  • C diff toxin
  • Cdiff
  • Clostridioides difficile
  • Clostridium difficile
  • CDIFF EIA
Toxigenic Clostridioides difficile GDH Antigen and Toxin by EIA, Stool