3020127
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FISH Interphase

FISH INT
Example Reports
Abnormal
Normal

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Time Sensitive

Ordering Recommendation

Use to order individual or multiple oncology FISH probes if standard FISH panels are not desired. Refer to the listing of oncology FISH probes at https://www.aruplab.com/genetics/tests/fish-oncology.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Nondiluted bone marrow aspirate collected in a heparinized syringe.
Also acceptable: Bone marrow or whole blood collected in green (sodium heparin).

Specimen Preparation

Transfer 3 mL bone marrow to a green (sodium heparin) (Min: 1 mL) OR transport 5 mL whole blood (Min: 2 mL)

Storage/Transport Temperature

Preferred transport temp: Room temperature.

Unacceptable Conditions

Paraffin-embedded specimens. Clotted specimens.

Remarks

Desired FISH probe(s), specimen type, and pertinent clinical diagnosis are required with test order. Testing will not be performed until probe(s), specimen type, and diagnosis are provided; absence of this information will delay turnaround time.

Stability

Ambient: 2 days; Refrigerated: 2 days; Frozen: Unacceptable

Methodology

Fluorescence in situ Hybridization (FISH)

Performed

Sun-Sat

Reported

3-9 days

Reference Interval

Interpretive Data



Compliance Category

Laboratory Developed Test (LDT)

Note

Time required for testing can vary depending on specimen type and probes ordered.
Please indicate the names of probes needed for testing and specimen type. Refer to Ordering Recommendations for a link to available FISH probes.
Contact ARUP Genetics Service Support at extension 3301 to add a probe to a current specimen.
If more than one FISH probe is ordered, additional probe and analysis charges will be applied per probe.
Other specimen types may be acceptable, contact ARUP Genetics Support Services at extension 3301 for specific specimen collection and transportation instructions.
If chromosome analysis is not performed at ARUP on the same sample, Bone Marrow/PBL Culture Processing Fee (0093271) will be added to account for sample processing, and an additional charge will apply. If multiple FISH tests are ordered, 0093271 will only be applied to one of the FISH tests. If cell pellets or dropped cytogenetic slides are submitted, processing fee will not apply.
This test must be ordered using Oncology test request form #43099 or through your ARUP interface.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
01/20/2026
X
N/A

CPT Codes

88271; 88275

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Components

Component Test Code* Component Chart Name LOINC
3020330 EER FISH Interphase 11526-1
3020331 FISH Interphase 57802-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • 1p32 (CDKN2C), 1p Loss/Deletion, CDKN2C/CKS1B (1p/1q)
  • 1q21 (CKS1B), 1q Gain/Amplification, with 1p32 (CDKN2C)
  • 1q25 (ABL2) Breakapart, ABL2 Rearrangement
  • GATA2::MECOM (RPN1-EVI1) Fusion, inv(3)(q21q26.2), t(3;3)(q21;q26.2), inv(3)/t(3;3)
  • 3q26 (MECOM) Breakapart, MECOM (EVI1) Rearrangement (non-NY approved)
  • 3q27 (BCL6) Breakapart, BCL6 Rearrangement
  • +4, Trisomy 4, Hyperdiploidy
  • IGH::FGFR3 Fusion, t(4;14)(p16;q32)
  • 4q12 FIP1L1::PDGFRA Fusion, PDGFR-alpha/PDGFRA Rearrangement, PDGFRA-CHIC2-FIP1L1 with CHIC2 Deletion
  • 5q31 (EGR1) Deletion, Loss/Deletion 5q, del(5q), -5, Monosomy 5, with 5p15 (D5S23)
  • 5q32 (CSF1R) Breakapart, CSF1R Rearrangement
  • 5q32 (PDGFRB) Breakapart, PDGFR-beta/PDGFRB Rearrangement
  • 7p12 IKZF1 (IKAROS) Deletion, Loss/Deletion 7p, del(7p)
  • 7q31 (D7S486) Deletion, Loss/Deletion 7q, del(7q), -7, Monosomy 7
  • +8, Trisomy 8
  • 8p11.2 (FGFR1) Breakapart, FGFR1 Rearrangement
  • RUNX1T1::RUNX1 (ETO::AML1) Fusion, t(8;21)(q22;q22), iAMP21, +8, +21
  • 8q24 (MYC) Breakapart, MYC rearrangement
  • IGH::MYC Fusion/Rearrangement, t(8;14)(q24;q32)
  • +9, Trisomy 9, Hyperdiploidy
  • 9p24 (JAK2) Breakapart, JAK2 Rearrangement, +9, Trisomy 9, Hyperdiploidy
  • 9p21 (CDKN2A) Deletion, Loss/Deletion 9p, del(9p)
  • 9q34 (ABL1) Breakapart, ABL1 Rearrangement
  • BCR::ABL1 Fusion, Philadelphia (Ph) chromosome, t(9;22)(q34;q11.2)
  • +10, Trisomy 10, Hyperdiploidy
  • IGH::CCND1 Fusion/Rearrangement, t(11;14)(q13;q32), +11
  • 11p15 (NUP98) Breakapart, NUP98 Rearrangement
  • 11q22 (ATM) deletion, Loss/Deletion 11q, del(11q)
  • 11q23 (KMT2A) Breakapart, KMT2A (MLL) Rearrangement, Loss/Deletion 11q, del(11q)
  • +12, Trisomy 12
  • 12p13 (ETV6) Breakapart, ETV6 Rearrangement, Loss/Deletion 12p, del(12p)
  • ETV6::RUNX1 (TEL-AML1) Fusion, t(12;21)(p13;q22), iAMP21, Loss/Deletion 12p, del(12p), +21
  • 13q14 (D13S319) Deletion, Loss/Deletion 13q, with 13q34 (LAMP1)
  • 14q32 (TCL1A) Breakapart, TCL1A Rearrangement
  • 14q32 (IGH) Breakapart, IGH Rearrangement
  • IGH::MAF Fusion/Rearrangement, t(14;16)(q32;q23)
  • IGH::BCL2 Fusion/Rearrangement, t(14;18)(q32;q21)
  • IGH::MAFB Fusion/Rearrangement, t(14;20)(q32;q12)
  • PML::RARA Fusion, t(15;17)(q24;q21), +15, +15q, +17, +17q
  • 16q22 (CBFB) Breakapart, CBFB Rearrangement
  • CBFB::MYH11 Fusion, t(16;16)(p13.1;q22), inv(16)(p13.3q22), inv(16)/t(16;16)
  • +17, Trisomy 17, Hyperdiploidy
  • del(17)(p13.1) (TP53) Deletion, TP53 (p53) Deletion
  • 18q21 (MALT) Breakapart, MALT1 Rearrangement
  • 19p13.3 (TCF3) Breakapart, TCF3 (E2A) Rearrangement
  • 19p13.2 (EPOR) Breakapart, EPOR Rearrangement
  • 20q12 (D20S108) Deletion, Loss/Deletion 20q, del(20q), with 20q13 (MYBL2)
  • 21q22 (RUNX1) Breakapart, RUNX1 Rearrangement, iAMP21, +21
  • 21q22 (RUNX1) amp, with 12p13 (ETV6), iAMP21
  • 22q12 (EWSR1) Breakapart, EWSR1 Rearrangement
  • Xp22/Yp11 (CRLF2) Breakapart/Deletion, CRLF2 Rearrangement, CRLF2 5' Deletion/P2RY8::CRLF2 Fusion
  • X and Y centromere (CEP X/Y), DXZ1, DYZ3
FISH Interphase