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Viral Hepatitis Prenatal Panel

VPRENATHEP

Ordering Recommendation

Use for hepatitis B virus (HBV) and hepatitis C virus (HCV) prenatal screening. If initial result is positive for HCV, test reflexes to quantitative nucleic acid amplification (NAAT) to confirm HCV infection.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube (SST). Also acceptable: Lavender (EDTA) or pink (K2EDTA).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 3.5 mL serum or plasma to an ARUP standard transport tube (Min: 3.0 mL). This test requires a dedicated transport tube submitted only for VPRENATHEP testing.

Storage/Transport Temperature

Frozen

Unacceptable Conditions

Specimen: Body fluids other than serum or plasma.
Condition: Heparinized plasma. Specimens containing particulate material or obvious microbial contamination. Heat-inactivated, severely hemolyzed, or lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 24 hours; Refrigerated: 6 days; Frozen: 2 months (avoid freeze/thaw cycles).

Methodology

Qualitative Chemiluminescent Immunoassay (CLIA) / Quantitative Polymerase Chain Reaction (PCR)

Performed

Sun-Sat

Reported

1-4 days

Reference Interval

Test Number
 Components
 Reference Interval
  Hepatitis B Surface Antigen, Prenatal Negative
  Hepatitis C Antibody by CIA Interp Negative
  Hepatitis B Core Antibodies, Total Negative
  Hepatitis B Surface Antibody Negative

Interpretive Data

This test should not be used for blood donor screening, associated reentry protocols, or for screening human cells, tissues, and cellular- and tissue-based products (HCT/P).


Components Reference Interval
Hepatitis C Antibody by CIA Index 0.79 IV or less: Negative
0.80 to 0.99 IV: Equivocal
1.00 to 10.99 IV: Low Positive
11.00 IV or greater: High Positive
Hepatitis B Surface Antibody Less than 10.00 IU/L: Negative
Greater than or equal to 10.00 IU/L: Positive

Compliance Category

FDA

Note

Order this test only for prenatal specimens. If results for HBsAg screen are reactive (=1.0), then HBsAg Confirmation, Prenatal will be added. Additional charges apply.

If the anti-HCV screening result is low positive or high positive, the Hepatitis C Virus (HCV) by Quantitative NAAT will be added. Additional charges apply.

For HBsAb, results greater than 1,000.00 IU/L are reported as greater than 1,000.00 IU/L.

The HBcAb assay tests for IgG and IgM antibodies, but does not differentiate between them.

This test requires a dedicated transport tube submitted only for VPRENATHEP testing.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
06/09/2025
X
N/A

CPT Codes

87340; 86803; 86706; 86704; if reflexed, add 87341; 87522

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Components

Component Test Code* Component Chart Name LOINC
0020090 Hepatitis B Surface Antibody 5193-8
0020091 Hepatitis B Core Antibodies, Total 13952-7
0020099 Hepatitis C Antibody by CIA Interp 13955-0
2002404 Hepatitis C Antibody by CIA Index 57006-9
2007574 Hepatitis B Surface Antigen, Prenatal 48767-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Anti-HCV
  • HCV Ab
  • HCV Antibody
  • HCVAB, Serum
  • Hepatitis C Viral Antibody, Serum
  • non-A, non-B Hepatitis
  • Prenatal hepatitis C Antibody with Reflex to HCV RNA Quantitative Real-Time PCR
  • Prenatal hepatitis C Antibody with Reflex to Hepatitis C Virus RNA Quantitative Real-Time PCR
  • Hepatitis C Virus (HCV) Antibody With Reflex to Quantitative Real-time PCR, prenatal
  • Hepatitis B surface antigen, prenatal
  • Prenatal HBsAg confirmation
  • Prenatal Reflexive Panel
  • Anti Core Antibodies
  • Anti-Hepatitis Bc
  • Antibody to Hepatitis Bc
  • Core Antibody IgG/IgM
  • Hep B Core Ab IgG/IgM, Hep Bc Ab IgG/IgM
  • Hep B Core Total Ab
  • Hepatitis B Immune Status Profile, Serum
  • HBV Core Total
  • HBsAB
  • Hepatitis B Immunity
  • Anti-Hepatitis Bs
  • Antibody Titer to Hep B Surface Ag
  • Antibody to Hepatitis B Surface Antigen
  • HBV Hep B Surface Ab
  • Anti-HBs Titer, S
  • Hepatitis Bs
  • Hepatitis B Surface Antibody, Quantitative
Viral Hepatitis Prenatal Panel