3019803
print

Angelman Syndrome and Prader-Willi Syndrome by Methylation-Specific MLPA, Fetal

AS-PWSDDFE

Icon

Additional Technical Information

Ordering Recommendation

Prenatal diagnostic test for Angelman syndrome or Prader-Willi syndrome.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Fetal Specimens:
Two T-25 flasks at 80 percent confluent of cultured amniocytes
AND
Maternal Whole Blood Specimen: Lavender (EDTA), pink (K2EDTA), or yellow (ACD solution A)

Specimen Preparation

Fetal Specimens:
Cultured Amniocytes: Fill flasks with culture media. Transport two T-25 flasks at 80 percent confluent of cultured amniocytes filled with culture media. Backup cultures must be retained at the client's institution until testing is complete. If ARUP receives a sample below the minimum confluence, CG GRW&SND (0040182) will be added on by ARUP, and additional charges will apply. If clients are unable to culture specimens, CG GRW&SND should be added to initial order.
Maternal Whole Blood Specimen: Transport 3 mL whole blood (Min: 1 mL)

Storage/Transport Temperature

Fetal Specimens:
Cultured Amniocytes: CRITICAL ROOM TEMPERATURE. Must be received within 48 hours of shipment due to viability.
Maternal Whole Blood Specimen: Refrigerated. Also acceptable: Ambient.

Unacceptable Conditions

Frozen specimens in glass collection tubes.

Remarks
Stability

Fetal Specimens:
Cultured Amniocytes: Room temperature: 48 hours; Refrigerated: Unacceptable; Frozen: Unacceptable
Maternal Whole Blood Specimen: Room temperature: 1 week; Refrigerated: 1 month; Frozen: Unacceptable

Methodology

Methylation-Specific Multiplex Ligation-Dependent Probe Amplification (MS-MLPA)

Performed

Varies

Reported

12-14 days
If culture is required, an additional 1 to 2 weeks is required for processing time.

Reference Interval

By Report

Interpretive Data

Refer to report.

Compliance Category

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
10/20/2025
X
N/A

CPT Codes

81331; 81265 Fetal Cell Contamination (FCC)

Are you an ARUP Client? Click here for your pricing.

Components

Component Test Code* Component Chart Name LOINC
0050548 Maternal Contamination Study Fetal Spec 59266-7
0050612 Maternal Contam Study, Maternal Spec 66746-9
3019804 AS-PWS Fetal Specimen 66746-9
3019805 AS-PWS Fetal Interpretation 41117-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Prader-Labhart-Willi Syndrome
Angelman Syndrome and Prader-Willi Syndrome by Methylation-Specific MLPA, Fetal